Association between hypoglycaemia and disability at different blood glucose level thresholds (multivariable analysis)
| Threshold of 2.6 mmol | Threshold of 3.0 mmol/L | |||||||
| In first 12 hours | p Value | Over 72 hours | p Value | In first 12 hours | p Value | Over 72 hours | p Value | |
| Adjusted OR and 95% CI (HIE stage) | ||||||||
| Nil episodes | Baseline | Baseline | ||||||
| One episode | 0.52 (0.06 to 4.63) | 0.558 | 0.60 (0.07 to 5.33) | 0.648 | 0.52 (0.06 to 4.56) | 0.555 | 0.55 (0.06 to 4.94) | 0.596 |
| Two episodes | 1.13 (0.12 to 10.72) | 0.917 | 1.029 (0.11 to 9.38) | 0.980 | 0.83 (0.09 to 7.52) | 0.868 | 1.52 (0.16 to 14.99) | 0.719 |
| Three or more episodes | 11.90 (2.51 to 56.40) | 0.002 | 6.91 (1.63 to 29.26) | 0.009 | 8.04 (1.84 to 35.26) | 0.042 | 3.49 (0.98 to 12.33) | 0.053 |
| Adjusted OR and 95% CI (HIE stage and hyperglycaemia) | ||||||||
| Nil episodes | Baseline | Baseline | ||||||
| One episode | 0.62 (0.07 to 5.61) | 0.674 | 0.67 (0.08 to 5.95) | 0.719 | 0.56 (0.06 to 4.96) | 0.605 | 0.61 (0.07 to 5.46) | 0.656 |
| Two episodes | 1.46 (0.14 to 15.56) | 0.752 | 1.36 (0.13 to 13.95) | 0.797 | 0.95 (0.10 to 8.95) | 0.965 | 1.62 (0.16 to 16.19) | 0.682 |
| Three or more episodes | 16.86 (3.00 to 94.66) | 0.001 | 7.93 (1.76 to 35.77) | 0.007 | 9.87 (2.05 to 47.55) | 0.004 | 3.98 (1.07 to 14.85) | 0.04 |
| Adjusted OR and 95% CI (HIE stage and time to start TH) | ||||||||
| Nil episodes | Baseline | Baseline | ||||||
| One episode | 0.52 (0.06 to 4.87) | 0.567 | 0.60 (0.07 to 5.58) | 0.654 | 0.531 (0.06 to 4.83) | 0.575 | 0.54 (0.06 to 5.02) | 0.589 |
| Two episodes | 0 | 0.999 | 0.92 (0.10 to 8.93) | 0.943 | 0 | 0.999 | 1.52 (0.15 to 15.73) | 0.722 |
| Three or more episodes | 12.08 (2.43 to 59.86) | 0.002 | 6.06 (1.25 to 29.36) | 0.025 | 8.16 (1.78 to 37.37) | 0.007 | 2.84 (0.73 to 11.11) | 0.133 |
| Adjusted OR and 95% CI (HIE stage, hyperglycaemia and time to start TH) | ||||||||
| Nil episodes | Baseline | Baseline | ||||||
| One episode | 0.67 (0.07 to 6.41) | 0.731 | 0.72 (0.08 to 6.67) | 0.772 | 0.60 (0.07 to 5.49) | 0.652 | 0.63 (0.07 to 5.87) | 0.685 |
| Two episodes | 0 | 0.999 | 1.40 (0.12 to 15.90) | 0.787 | 0 | 0.999 | 1.70 (0.16 to 17.95) | 0.661 |
| Three or more episodes | 20.46 (3.04 to 137.80) | 0.002 | 7.87 (1.44 to 42.98) | 0.017 | 11.13 (2.06 to 59.89) | 0.005 | 3.48 (0.82 to 14.74) | 0.090 |
HIE, hypoxic ischaemic encephalopathy; TH, therapeutichypothermia.