Population pharmacokinetic parameter estimates
| Base model | Final model | Bootstrap (977/1000 successful) | |
| Parameters | Population mean (%RSE) | Median (2.5 to 97.5 percentile) | |
| Elimination rate (1/hour) | 0.0317 (13%) | 0.0408 (15%) | 0.0411 (0.0318 to 0.0558) |
| Volume (L) | 216 (22%) | 233 (17%) | 228 (167 to 312) |
| Absorption rate (1/hour) | 3.43 (fixed) | 3.43 (fixed) | 3.43 (fixed) |
| Volume: age exponent | – | 0.775 (13%) | 0.780 (0.601 to 1.01) |
| Elimination rate: creatinine clearance exponent | – | 0.850 (24%) | 0.842 (0.470 to 1.25) |
| Fluconazole elimination rate (1/hour) | – | 0.0268 (5%) | 0.0267 (0.0234 to 0.0321) |
| Between-subject variability | |||
| ωke 2 | 0.219 (51%) | 0.262 (40%) | 0.256 (0.0858 to 0.590) |
| ωV 2 | 0.991 (27%) | 0.329 (35%) | 0.291 (0.0637 to 0.518) |
| Residual error | SD (%RSE) | ||
| Additive (µg/L) | 4.24 (14%) | 3.69 (13%) | 3.65 (3.16 to 4.14) |