Table 2

Summary of cause of death attribution by reviewers for deaths classified as TRM

Case	Diagnosis	CRA 1	CRA 2	Consultant 1	Consultant 2
J	AML prior to HSCT	Immunomediated	Immunomediated	Immunomediated	Immunomediated
M	ATRT	Acute symptomatic intracranial haemorrhage	Acute symptomatic intracranial haemorrhage	Not reported	Acute symptomatic intracranial haemorrhage
V	AML	Infection	Infection	Infection	Infection
X	B cell ALL	Acute symptomatic intracranial haemorrhage	Acute symptomatic intracranial haemorrhage	Infection	Infection
Y	T cell ALL	Respiratory	Infection	Acute symptomatic intracranial haemorrhage	Infection
Z	B cell ALL	Respiratory	Infection	Respiratory	Infection
AA	B cell ALL	Infection	Infection	Infection	Infection
AB	Ependymoma	Not reported	Infection	Not reported	Infection
AC	T cell ALL	Worsening symptomatic graft versus host disease	Worsening symptomatic graft versus host disease	Worsening symptomatic graft versus host disease	Acute symptomatic pulmonary haemorrhage
AD	B cell ALL post-HSCT	Unclear	Difficult case	Worsening symptomatic graft versus host disease	Acute kidney Injury

Bold font=probable causes of death.
ALL, acute lymphoblastic leukaemia; AML, acute myeloid lukemia; ATRT, atypical teratoid rhabdoid tumour; CRA, clinical research associates; HSCT, haematopoietic stem cell transplant; TRM, treatment-related mortality.