Primary composite outcome of survival free of major neurosensory impairment at 2–5 years corrected gestational age
| Probiotic group n=373 | Placebo group n=362 | Relative risk (95% CI) | P value | |
| Survival without major neurosensory impairment* N (%) | 281 (75.3) | 271 (74.9) | 1.01 (0.93 to 1.09) | 0.88 |
| Subgroup analyses: | ||||
| Gestation | 0.08† | |||
| <28 weeks, n (%) ≥28 weeks, n (%) | 104 (63.0) 177 (85.1) | 118 (69.0) 153 (80.1) | 0.91 (0.78 to 1.07) 1.06 (0.97 to 1.16) | 0.25 0.19 |
| Birth weight | 0.62† | |||
| <1000 g, n (%) ≥1000 g, n (%) | 116 (65.5) 165 (84.2) | 113 (66.5) 158 (82.3) | 0.99 (0.85 to 1.15) 1.02 (0.94 to 1.12) | 0.85 0.62 |
*Major neurosensory impairment=motor impairment AND/OR cognitive impairment AND/OR blindness AND/OR deafness.
†Interaction P value.