Original ArticleOral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates
Section snippets
Patient Population
Preterm neonates, <1500 g birth weight, who were admitted to the neonatal intensive care unit of the Shaare Zedek Medical Center between September 2001 and September 2004, and who began feeding on a weekday, were recruited for study on the day that they were to begin feeds. The study was approved by our institutional review board, and parental consent was obtained. The infants were prospectively and randomly assigned to one of two groups. The study group received their regular feeds plus a
Results
Of the 145 babies analyzed, 72 were randomized to the study group and 73 to the control group (Table I). No significant differences between the groups were detected. There were no differences in the incidence of culture-proven sepsis of any kind and no differences in the amount of time spent receiving antibiotic therapy.
Discussion
Probiotics may protect against NEC by shifting the intestinal ecological balance from a potentially harmful microflora to one that would be predominantly beneficial to the host.10 The two principal kinds of probiotic bacteria are members of the genera Lactobacillus and Bifidobacterium, which predominate in the normal gut flora of healthy, breastfed, term neonates. Furthermore, probiotics offer protection by strengthening the intestinal mucosal barrier function, which, in turn, impedes the
References (24)
- et al.
Gut flora in health and disease
Lancet
(2003) - et al.
Pathogenesis of neonatal necrotising enterocolitis
Lancet
(1982) Interactions mediating bacterial translocation in the immature intestine
J Nutriion
(2000)- et al.
Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model
Gastroenterology
(1999) Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit
Int J Infect Dis
(1999)- et al.
Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus
Lancet
(1994) - et al.
Development of the intestinal flora in very low birthweight infants compared to normal full-term newborns
Eur J Ped
(1985) - et al.
Development of gut colonisation in pre-term neonates
J Med Microbiol
(1982) - et al.
Stool microflora in extremely low birthweight infants
Arch Dis Child Fetal Neonatal
(1999) - et al.
Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis
FASEB J
(2001)
Quantitative changes in faecal microflora preceding necrotising enterocolitis in premature neonates
Arch Dis Child
Factors influencing the presence of fecal lactobacilli in early infancy
Arch Dis Child
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Drs Bromiker and Wilschanski contributed equally to the research culminating in this article.
Supported by Mr. and Mrs. Stephen Hammerman and the Mirsky Research Fund #18003697.