Abstract
We report a child with acute lymphocytic leukaemia who developed simultaneous osteonecrosis of vertebrae and cerebral thrombosis during L-asparaginase therapy. Fibrinogen, antithrombin III and plasminogen were decreased. Fresh frozen plasma in addition to antithrombin III concentrates were used to replenish these haemostatic proteins. L-asparaginase induced coagulopathy may cause osteonecrosis.
MeSH terms
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Adolescent
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Antithrombin III / analysis
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Asparaginase / adverse effects*
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Asparaginase / therapeutic use
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Female
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Humans
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Magnetic Resonance Imaging
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Osteonecrosis / blood
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Osteonecrosis / chemically induced*
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Osteonecrosis / diagnosis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Spinal Diseases / blood
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Spinal Diseases / chemically induced*
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Spinal Diseases / diagnosis
Substances
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Antithrombin III
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Asparaginase