Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia during L-asparaginase therapy

Eur J Pediatr. 1989 Dec;149(3):162-3. doi: 10.1007/BF01958270.

Abstract

We report a child with acute lymphocytic leukaemia who developed simultaneous osteonecrosis of vertebrae and cerebral thrombosis during L-asparaginase therapy. Fibrinogen, antithrombin III and plasminogen were decreased. Fresh frozen plasma in addition to antithrombin III concentrates were used to replenish these haemostatic proteins. L-asparaginase induced coagulopathy may cause osteonecrosis.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antithrombin III / analysis
  • Asparaginase / adverse effects*
  • Asparaginase / therapeutic use
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Osteonecrosis / blood
  • Osteonecrosis / chemically induced*
  • Osteonecrosis / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Spinal Diseases / blood
  • Spinal Diseases / chemically induced*
  • Spinal Diseases / diagnosis

Substances

  • Antithrombin III
  • Asparaginase