Abstract
We treated two children with neuroblastoma and during the course of chemotherapy, avascular necrosis of the femoral head occurred. The main pathogenetic factor of this necrosis may be the toxic effect of cyclophosphamide.
MeSH terms
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Adrenal Gland Neoplasms / drug therapy
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Antineoplastic Combined Chemotherapy Protocols
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Bone Neoplasms / drug therapy*
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Bone Neoplasms / secondary
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Child, Preschool
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / adverse effects*
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Doxorubicin / administration & dosage
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Femoral Neoplasms / drug therapy
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Femoral Neoplasms / secondary
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Femur Head Necrosis / chemically induced*
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Humans
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Male
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Mediastinal Neoplasms / drug therapy
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Neuroblastoma / drug therapy*
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Vincristine / administration & dosage
Substances
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Vincristine
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Doxorubicin
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Cyclophosphamide