Laboratory work has confirmed that general anesthetics cause increased neuronal
apoptosis and changes to the morphology of dendritic spines in the developing brains of …

The brain is vulnerable during the perioperative period in people of all ages.
Neurobehavioural disturbances are common complications of perioperative care …

Anesthetic agents disrupt neurodevelopment in animal models, but evidence in humans is
mixed. The morphologic and behavioral changes observed across many species predicted …

Background Preclinical data suggest that general anaesthetics affect brain development.
There is mixed evidence from cohort studies that young children exposed to anaesthesia …

Background In laboratory animals, exposure to most general anaesthetics leads to
neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition …

BACKGROUND: Mortality is a basic measure for quality and safety in anesthesia. There are
few anesthesia-related mortality data available for pediatric practice. Our objective for this …

Introduction: Immature animals exposed to anesthesia display apoptotic neurodegeneration
and neurobehavioral deficits. The safety of anesthetic agents in children has been evaluated …

Background: Postoperative apnea is a complication in young infants. Awake regional
anesthesia (RA) may reduce the risk; however, the evidence is weak. The General …

Background: In children anxiety at induction of anesthesia is a common and important
aspect of the psychological impact of anesthesia and surgery. Previous studies examining …

IMPLICATIONS: This study determined the incidence of awareness during anesthesia in
children. Eight-hundred-sixty-four children aged 5 to 12 yr who had undergone general …