Article Text

Download PDFPDF

A protocol for quality improvement programme to reduce central line-associated bloodstream infections in NICU of low and middle income country
  1. Ali Shabbir shabbir Hussain1,
  2. Syed Rehan Ali2,
  3. Shabina Ariff2,
  4. Saba Arbab2,
  5. Simon Demas2,
  6. Jehan Zeb2,
  7. Arjumand Rizvi2
  1. 1 Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
  2. 2 Department of Pediatrics, The Aga Khan University Hospital, Karachi, Pakistan
  1. Correspondence to Dr Ali Shabbir shabbir Hussain; ali.hussain{at}aku.edu

Abstract

Introduction Central line-associated bloodstream infections (CLABSI) are the most important cause of morbidity and mortality in critically ill patients. Evidence-based interventions when used in form of a bundle have proven to decrease CLABSI. Our unit has a high CLABSI rate (9/1000 central line days). Therefore, we intend to introduce evidence-based CLABSI prevention package in our practice to improve CLABSI rates in our NICU within limited resources.

Methods and analysis The study will be conducted using preanalysis and postanalysis design from January 2016 to December 2017. It is going to be conducted in three phases with phase I being the preimplimentation phase where retrospective data will be collected. Phase II, implementation phase, where the CLABSI prevention package will be introduced and phase III will be follow-up to see the impact. Primary outcome will be reduction in CLABSI rates.

Analysis plan and reporting For all three phases, descriptive analysis will be performed. Nominal data will be presented as mean±SD, whereas categorical data will be presented as frequencies and percentages. To compare the effect of intervention we will use independent sample t-test for continuous outcomes, whereas Χ2 test will be used for categorical outcomes. Relative risk ratios, 95% CI, and p values will be determined. Incidence density will be calculated and Poisson regression will be used to determine factors associated with incidence of CLABSI. Microbiological profiles and antimicrobial resistance pattern will be reported as pan sensitive, multidrug-resistant organism and carbapenem-resistant organism. SQUIRE V.2.0 guidelines will be used for manuscript writing and reporting.

  • neonatology
  • paediatric practice
  • infectious diseases

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors ASsH and SRA conceptualised and wrote the initial draft. SA reviewed and revised the manuscript. ASsH, SA,SD and JZ contributed to the development and implementation of the study interventions. AR contributed to the study design and analysis plan. All authors contributed equally in the final approval of the submitted version of the manuscript.

  • Competing interests None declared.

  • Ethics approval Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.