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Original article
Anti-epileptic drug utilisation in paediatrics: a systematic review
  1. Oluwaseun Egunsola1,
  2. Imti Choonara1,
  3. Helen M Sammons1,2
  1. 1 Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Derbyshire Children's Hospital, Derby, UK
  2. 2 Department of Paediatrics, North Devon District Hospital, Raleigh Park, Barnstaple, Devon, UK
  1. Correspondence to Dr Oluwaseun Egunsola; seunegunsola{at}yahoo.com

Abstract

Objectives This study aims to determine global anti-epileptic drug (AED) utilisation prevalence and describe utilisation trends in different countries.

Methods Databases Embase (1980–May 2017), Medline (1946–May 2017) and PubMed were searched for original research on AED utilisation. All paediatric national or regional database studies and surveys were included.

Results Twenty-one studies were identified. Five were excluded from the analysis as the data were collected before 2005, leaving 16 studies. Monotherapy regimen varied between 58% and 94% in different countries. In several of the studies, sodium valproate was the most frequently prescribed AED. However, there is a trend towards increasing utilisation of new-generation AEDs, particularly levetiracetam, in some countries.

Conclusion Monotherapy was used in 58%–94%of patients. There is increasing utilisation of the new-generation AEDs, in particular lamotrigine, levetiracetam and topiramate. Old-generation AEDs are still used in the majority of patients. There is a need for up-to-date studies to determine the prevalence of AEDs in children.

  • epilepsy
  • polytherapy
  • prescription
  • children

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Footnotes

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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