Article Text

Download PDFPDF

Original article
Bowel preparation for elective procedures in children: a systematic review and meta-analysis
  1. Morris Gordon1,2,
  2. Fiona Karlsen2,
  3. Sahira Isaji2,
  4. Guan-Ong Teck2
  1. 1 School of Medicine and Dentistry, University of Central Lancashire, Preston, UK
  2. 2 Department of Paediatrics, Blackpool Victoria Hospital, Blackpool, UK
  1. Correspondence to Dr Morris Gordon; Mgordon{at}uclan.ac.uk

Abstract

Objective Reviews have investigated preparation for colonoscopy, but not for surgery, They are also often limited to patients up to 16 years, despite many paediatric gastroenterologists caring for older patients. We carried out a systematic review investigating the optimum bowel preparation agents for all indications in children and young people.

Design A Cochrane format systematic review of randomised controlled trials (RCTs). Data extraction and assessment of methodological quality were performed independently by two reviewers. Methodological quality was assessed using the Cochrane risk of bias tool.

Patients Young people requiring bowel preparation for any elective procedure, as defined by the primary studies.

Interventions RCTs comparing bowel preparation with placebo or other interventions.

Main outcome measures Adequacy of bowel preparation, tolerability and adverse events.

Results The search yielded 2124 results and 15 randomised controlled studies (n=1435)but heterogeneity limited synthesis. Meta-analysis of two studies comparing polyethylene glycol (PEG) with sodium phosphate showed no difference in the quality of bowel preparation (risk ratio (RR) 1.27(95% CI 0.66 to 2.44)). Two studies comparing sodium picosulfate/magnesium citrate with PEG found no difference in bowel preparation but significantly higher number of patients needing nasogastric tube insertion in the polyethylene glycol-electrolyte lavage solution (RR 0.04(95% CI 0.01 to 0.18), 45 of 117 in PEG group vs 2 of 121 in sodium picosulfate group). Meta-analysis of three studies (n=241) found no difference between PEG and sennasoids (RR 0.73(95% CI 0.31 to 1.71)).

Conclusions The evidence base is clinically heterogeneous and methodologically at risk of bias. There is evidence that all regimens are equally effective. However, sodium picosulfate was better tolerated than PEG. Future research is needed with all agents and should seek to consider safety and tolerability as well as efficacy.

  • bowel preparation
  • bowel clearance
  • colonoscopy
  • systematic review

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors All authors contributed to and approved the final manuscript. MG conceived the project, supported analysis and contributed in writing the paper. SI and FK led the search, extraction and analysis. G-OT led the analysis and write-up.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All data available on request.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.