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Original article
Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres
  1. Francis J Gilchrist1,2,
  2. Richard Buka2,
  3. Mary Jones3,
  4. Sheng Ang Ho2,
  5. Warren Lenney2,
  6. William D Carroll1,2
  1. 1 Institute of Applied Clinical Science, Keele University, Keele, UK
  2. 2 Academic Department of Child Health, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke on Trent, UK
  3. 3 Department of Radiology, Royal Stoke University Hospital, Stoke on Trent, UK
  1. Correspondence to Dr Francis J Gilchrist; francis.gilchrist{at}uhnm.nhs.uk

Abstract

Objectives Chest CT is increasingly used to monitor disease progression in children with cystic fibrosis (CF) but there is no national guideline regarding its use. Our objective was to assess the indications for undertaking chest CT and the protocols used to obtain scans.

Design, Setting and participants An electronic questionnaire was developed to assess clinicians views on chest CT in children with CF. It included general questions on perceived benefits and specific questions about its role in five clinical scenarios. It was sent to the clinical lead in 27 UK paediatric CF centres. A separate questionnaire was developed to collect the technical details of chest CT in children with CF. It was sent to the superintendent radiographer at each of the 27 centres.

Results Responses were obtained from 27 (100%) clinical leads and 22 (81%) superintendent radiographers. 93% clinicians reported chest CT useful in monitoring disease progression and 70% said it frequently altered management. Only 5 (19%) undertook routine scans. To aid diagnosis, 81% performed chest CT in non-tuberculous mycobacterial disease and 15% in allergic bronchopulmonary aspergillosis. There was wide variation in the perceived need for and/or timing of chest CT in children with reduced lung function with no benefit from intravenous antibiotics, new cystic changes on chest X-ray, and lobar collapse. The radiographers reported using a mixture of helical (volumetric) and axial scans depending on the clinical question, the age and the cooperation of the child. When indicated, 6 (27%) used sedation and 16 (73%) general anaesthetic. Only 1 (5%) used intravenous contrast routinely and 3 (14%) obtained expiratory images routinely.

Conclusions There is marked variation in the use of chest CT in children with CF and in the scan protocols. The lack of a national guideline is likely to be contributing to this lack of standardisation.

  • cystic fibrosis
  • respiratory
  • imaging

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • Contributors FJG conceptualised and designed the study; he developed the questionnaires and wrote the first draft of the article article. RB assisted with the collection and analysis of data. MJ and WL helped develop the questionnaires. MJ, SAH, WL and WDC assisted with analysis and interpretation of results. All authors reviewed and revised the manuscript and approved the final manuscript as submitted.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All data from this article is available upon request to the corresponding author.