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EBV-requisitioning physicians’ guess on fatigue state 6 months after acute EBV infection
  1. Tarjei Tørre Asprusten1,
  2. Maria Pedersen2,
  3. Eva Skovlund3,4,
  4. Vegard Bruun Wyller1,5
  1. 1 Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway
  2. 2 Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Akershus, Norway
  3. 3 Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway
  4. 4 Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway
  5. 5 Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Akershus, Norway
  1. Correspondence to Dr Tarjei Tørre Asprusten; tarjei.asprusten{at}


We assessed referring medical practitioner’s ability to predict chronic fatigue development in adolescents presenting with acute infectious mononucleosis. Compared with ‘not fatigued’ being predicted as ‘unsurely fatigued’ and ‘likely fatigued’ were both strongly associated with developing fatigue 6 months later (OR 2.5, 95% CI 1.16% to 5.47% and 3.2, 95% CI 1.19% to 8.61%, respectively, P=0.012). The positive and negative predictive values were 66% and 62%, respectively. Disentangling the physician’s intuition may be of interest in further investigations of risk factors and prophylactic factors for fatigue development.

  • adolescent health
  • chronic fatigue syndrome

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  • Contributors TTA, MP and VBW conceptualised and designed the study, carried out the statistical analyses, drafted the initial manuscript and reviewed and revised the manuscript. ES supervised statistical analyses and critically reviewed and revised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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