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Haematocrit in <35 weeks preterm infants who received at least 60 seconds of delayed cord clamping: a retrospective observational study
  1. Matthew JR Nudelman1,2,3,
  2. Keshav Goel1,
  3. Priya Jegatheesan1,2,
  4. Dongli Song1,2,
  5. Angela Huang1,
  6. Balaji Govindaswami1,2
  1. 1 Pediatrics / Newborn Medicine, Santa Clara Valley Medical Center: Hospital and Clinics, San Jose, California, United States
  2. 2 Stanford, School of Medicine, Palo Alto, California, United States
  3. 3 University of California, San Francisco, San Francisco, California, United States
  1. Correspondence to Dr Matthew JR Nudelman; matthew.nudelman{at}hhs.sccgov.org

Abstract

Objective To describe haematocrit at birth in preterm infants who received ≥60 s of delayed cord clamping (DCC).

Design Retrospective observational study.

Setting A California public hospital with an American Academy of Pediatrics level 4 neonatal intensive care unit, with 3500–4000 deliveries annually.

Participants 467 preterm infants born at <35 weeks’ gestational age (GA) between January 2013 and December 2018.

Primary and secondary outcome measures Haematocrit reference ranges for 0–4 hours after birth and paired haematocrit differences between 0–4 and 4–24 hours.

Methods Haematocrits were obtained when clinically indicated and collected from arterial, venous and capillary sources. Haematocrits obtained after packed red blood cell transfusions were excluded. We summarised the first available haematocrit between 0 and 4 hours by GA strata. We used mixed-effects linear regression to describe the associations between haematocrit and predictor variables including GA, male sex and hours after an infant’s birth. We also compared paired haematocrits at 0–4 and 4–24 hours after birth.

Results The median GA of the 467 included infants was 33.3 weeks, birth weight was 1910 g and DCC duration was 60 s. The mean (95% CI) first haematocrit at 0–4 hours was 46.6 (45.0% to 48.1%), 51.2 (49.6% to 52.8%), 50.6 (49.1% to 52.1%), 54.3 (52.8% to 55.8%) and 55.6 (54.6% to 56.6%) for infants 23–29, 30–31, 32, 33 and 34 weeks’ GA strata, respectively. The subanalysis of 174 infants with paired haematocrits at 0–4 and 4–24 hours showed that for each additional hour after birth, the mean (95% CI) haematocrit increased by 0.2 (0.1% to 0.3%), 0.2 (0.1% to 0.4%) and 0.1 (0.0% to 0.2%) for infants in 23–29, 30–31 and 32 weeks’ GA strata, respectively. The subanalysis showed no change between the paired haematocrits in the 33 and 34 weeks’ GA strata.

Conclusions Our study describes haematocrit in preterm infants who received ≥60 s DCC as standard of care. Haematocrit during the first 0–4 hours in our study is higher than the previously described reference ranges prior to DCC becoming routine clinical practice. The paired second haematocrit at 4–24 hours is higher than haematocrit at 0–4 hours.

  • haematology
  • paediatric practice
  • neonatology

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • Contributors BG, PJ and DS conceptualised the study. BG, PJ, DS, MN and AH designed the study. MN, KG and AH performed the data collection. MN, KG and PJ designed and ensured valid data collection. MN, KG and PJ carried out the data analysis. MN, KG and PJ drafted the initial abstract and the manuscript. All authors critically reviewed and revised the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

  • Funding The authors received funding support for data collection for this study from Santa Clara County First 5.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved as a quality improvement project by the Institutional Review Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.

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