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In regards to your observational study : Oxygen saturation after birth in resuscitated neonates in Uganda, your findings of A high proportion of neonates resuscitated with PPV after birth failing to reach the AHA SpO2 target is probably due to the apnoeic neonates ≥34 weeks which were chosen in the first place. Secondly i didn't come across the maternal health status in your research. and that makes me wonder whether the mother's were previously diabetic, hypertensive, vaccinated? or maybe they were anemic. Inadequate hemoglobin concentration might be the cause of the subpar SpO2 targets. That being said hypoxic-ischaemic encephalopathy is absolutely certain. Further studies are needed to evaluate baseline data and the need for supplemental O2 and optimal SpO2 during PPV since the goal here is to have the right guidelines to act upon and save as many lives as we can.