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PP-106 Azoximer bromide in the tretment of children with pharyngeal lymphoid ring pathology
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  1. Vera Vavilova1,
  2. Alexsandr Vavilov1,
  3. Irina Nechaeva2,
  4. Vitaliy Tyulyukin2
  1. 1Kemerovo State Medical University
  2. 2Kuzbass Regional Children’s Clinical Hospital named after Y.A. Atamanov

Abstract

Aim To evaluate the efficacy of azoximer bromide in the treatment of pharyngeal lymphoid ring pathology in preschool children.

Material and Method 2463 children aged 3–6 years with pharyngeal lymphoid ring pathology were included in the study. In Group I (1350 patients) all patients received azoximer bromide intranasally at a dose of 0.15 mg/kg per day daily for a course of 10 days. Group II included 1113 preschoolers with a chronic nasopharyngeal infection who received symptomatic therapy. The efficacy was evaluated before and one month after the course of therapy.

Results Initially, before the beginning of prophylactic therapy, grade II nasopharyngeal tonsillar hypertrophy was registered in 75.0% of children in the treatment group and in 71.5% of children in the control group. Grade I nasopharyngeal tonsillar hypertrophy made up 25.0% and 28.5%, respectively. One month after the course of therapy the symptoms of adenoiditis were almost resolved in 80% of patients, nasal breathing was restored in 90.0% of patients, and the size of the nasopharyngeal tonsil decreased from grade II to grade I in 60.0% of patients. The improvement in rhinoscopic findings was noted in 83% of patients, and 75.6% of patients demonstrated a decrease in the incidence of acute respiratory infections from 5–8 to 2–3 cases per year. Endoscopic follow-up confirmed a decrease in the size of both nasopharyngeal and palatine tonsils in 65.9% of patients. An increase of lysozyme level in nasal secretion from 56.9±0.88% to 69.8± 0.45% (p<0.001) and S IgA from 0.18±0.005 g/L to 0.20±0.003 g/L (p<0.01) was registered under the azoximer bromide therapy. The effect persisted for 3.5 months.

Conclusions A prospective observation of children receiving azoximer bromide has demonstrated its efficacy in the treatment of pharyngeal lymphoid ring pathology. The obtained data allow to recommend including azoximer bromide in the treatment regimens for adenotonsillar pathology.

  • azoximer bromide
  • children
  • pharyngeal lymphoid ring

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