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OP-045 Morphine utilisation in ventilated infants born <32-week gestation: a retrospective observational study
  1. Mohammed Bahari
  1. Arrowe Park Hospital, Wirral University Teaching Hospital, Wirral, UK


Aim This study aimed to assess the use of morphine in premature infants undergoing ventilation in the Neonatal Intensive Care Unit (NICU) at Arrowe Park Hospital. Secondary objectives included examining associations between morphine use and ventilation duration, time to full feeding, incidences of intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), chronic lung disease (CLD), length of stay (LOS), use of inotropes, and occurrences of necrotizing enterocolitis (NEC).

Material and Method Conducted as a retrospective observational study from January 1st, 2022, to December 31st, 2022, in a tertiary NICU, in-born infants under 32 weeks gestation requiring invasive ventilation within their first seven days of life were included. Exclusions comprised postnatally transferred infants, those born after 31 weeks and 6 days gestation, and those not needing invasive ventilation. Data, drawn from electronic medical records, underwent descriptive analysis. Statistical tests (Chi-square, Fisher’s exact, Mann-Whitney) were used for significance determination (p<0.05).

Results Of 315 admitted infants, only 36 met the criteria, with 11 (30.5%) receiving morphine during ventilation (figure 1). No significant differences emerged between morphine recipients and non-recipients regarding sex, gestational age, CLD, ROP, days to full feeds, NEC, or LOS. However, morphine recipients were smaller (p=0.005), required longer ventilation (p=0.035), and more inotropes (p=0.038). Morphine recipients also exhibited significantly higher IVH incidence (p=<0.001) (table 1).

Abstract OP-045 Figure 1

Patient enrolment in the study

Abstract OP-045 Table 1

Comparison of clinical parameters between infants who received morphine and those who did not

Conclusions In conclusion, morphine use in ventilated preterm infants was lower than expected. Nonetheless, vigilant monitoring and staff feedback are vital to reducing its use further. Despite potential IVH risks and increased inotrope needs, larger sample sizes are needed for definitive conclusions.

  • morphine
  • IVH
  • premature infant
  • Ventilation
  • CLD

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