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OP-048 Metabolic-associated fatty liver disease factors in obese children
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  1. Olena Starets,
  2. Tetiana Khimenko,
  3. Iryna Shapovalenko,
  4. Anastasiia Pyrogova
  1. Odessa National Medical University, Department of Propedeutics of Pediatrics, Odesa, Ukraine

Abstract

Aim The metabolic-associated fatty liver disease (MAFLD), earlier called nonalcoholic fatty liver disease (NAFLD), is known like common reason of liver pathology in adolescents. The prevalence of MAFLD and risk factors associated with this condition in Ukrainian children are not clear. The aim of the research was to study the prevalence and patient associated risk factors of MAFLD in Ukrainian children

Material and Method A retrospective and prospective research conducted in 2020–2023. It included 202 children aged 9 to 18 years with overweight and obesity. Inclusion criteria were: body mass index (BMI) – >85th percentile for age/sex, age of children ≥ 9 years till < 18 years, absence of other causes of fatty liver disease (infectious, endocrine, genetic, immune, iatrogenic). We provided questioning, physical examination, laboratory evaluation (fasting lipid panel, liver functional test, HbA1c, vitamin D level). The screening diagnostic criteria for MAFLD was elevated level of alanine aminotrasferase (ALT) >80 U/l that last longer than 3 months.

Results The 32% of children in the cohort were overweight, the 51% - obese, 27% - severe obese. The 52% – were boys. MAFLD was confirmed in 19% of children. No one had any clinical presentation of advanced chronic liver disease. It was shown that MAFLD was associated with such factors: intrauterine growth retardation (IUGR) (3,39; 1,02–11,37), formula feeding (2,96; 1,36–6,44), male sex (2,33; 1,10–4,93), vitamin D deficiency (2,87; 1,16–7,12), prediabetes/diabetes (3,48; 1,68–7,20).

Conclusions Prevalence of MAFLD in cohort of children with overweight and obesity was 19%. The study showed that IUGR, formula feeding, male sex, vitamin D deficiency, prediabetes/diabetes were associated with presence of MAFLD and can be supposed like risk factors of this disease.

  • metabolic-associated fatty liver disease
  • children
  • obesity
  • overweight

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