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OP-097 Evaluation of neonatal outcomes in infants of mothers with diabetes mellitus and macrosomic infants
  1. Figen Kaşkır Şahin,
  2. Betül Ayşe Acunaş
  1. Trakya University


Aim To recognize the morbidities of babies born to diabetic mothers, to determine the effects of macrosomia that develops without diabetes and to determine their common or different aspects.

Material and Method Prenatal, natal and postnatal period characteristics, morbidity and mortality rates of macrosomic infants of both diabetic and non-diabetic mothers in the NICU and at the maternal bedside in the last 15 years, non-macrosomic NICU infants and infants with macrosomia of 4000–4499 g, 500–4999 g and >5000 g were evaluated by univariate and multivariate analyses.

Results Data from 534 infants were retrospectively analyzed. Among macrosomics, maternal blood glucose and HbA1c were higher, cardiac pathologies and polyhydramnios were more frequent in those with infant of diabetic mothers (IDM) (n=161) compared to those without IDM (n=154). Among the morbidities that were found to be significant in single analyses, the factors affecting hypoglycemia were found to be the presence of macrosomia (5.73-fold higher), increased 1st minute Apgar score (1.32-fold decrease), increased 5th minute Apgar score had 2.46-fold decreasing effect on birth traumas, increased maternal blood glucose increased sepsis 1.007-fold, and increased 5th minute Apgar score had 1.623-fold decreasing effect. In macrosomic infants, the development of transient tachypnea of neonate was 2.747 times higher, and an increase in the 5th minute Apgar score had 1.610-fold decreasing effect. In infants who underwent advanced resuscitation, the risk of developing Type 1 RDS was 4.342 times higher, and an increase in the 5-minute Apgar score had 1.764-fold decreasing effect on RDS. One unit increase in maternal blood glucose increased the risk of higher macrosomia level by 1.013 times.

Conclusions Our study shows that in addition to the presence of diabetes mellitus, maternal blood glucose control and the associated degree of macrosomia affect outcomes. Further study of the similarities and differences between IDM and macrosomic infants in larger samples may be instructive.

  • Infant of diabetic mother
  • macrosomia
  • newborn
  • mortality
  • morbidity

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