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OP-108 The effect of inhaled nitric oxide therapy on platelet values in neonates with persistent pulmonary hypertension
  1. Umit Ayse Tandircioglu,
  2. Yasemin Gulseven,
  3. Serdar Alan
  1. Kirikkale University Department of Pediatrics, Division of Neonatology


Aim Persistent pulmonary hypertension in neonates (PPHT) is a severe hypoxemia condition in newborn period. Inhaled nitric oxide (iNO) is commonly used for infants with PPHN. The aim of this study was to show the effects of iNO, one of the most common and effective treatments of PPHT, on platelet count, platelet mass index (PMI) and mean platelet volume (MPV).

Material and Method The study enrolled between 01.09.2022to01.09.2023 with diagnosed with PPHT. Demographic information, diagnoses and treatment modalities were obtained retrospectively from hospital records. The diagnosis of PPHT was confirmed by echocardiography (ECHO). Cases with PPHT during the study period were treated with standard treatment approach. If the oxygenation index (OI) was >25 despite ventilatory support, iNO treatment was initiated. Hematologic parameters before and after iNO treatment were compared using ordinal measurement.

Results Demographic data of 13 patients diagnosed with PPHT during the study period are given in the table 1. The number of infants who received iNO treatment for at least 24 hours or more was 9 and the median duration of treatment was 78 hours (34–192 hours). Three infants who received iNO treatment died on days 1, 3 and 9 of treatment. All of the patients had platelet counts <400x103 uL before iNO. Thrombocytosis (>400x103 uL) was found in six (67%) infants after iNO treatment. Mean platelet counts were 219x103 uL (186x103–356x103) before iNO treatment and 464x103 uL (144x103–610x103) after treatment, p: 0.051. There was a significant difference between pre-and post-treatment BMI and MPV values (2146.2 (1748.4- 3666.8)- 4420 (1314–6132), p: 0.038 and 9.7 fL (9–10.5),10.1(9–13), p: 0.021, respectively).

Abstract OP-108 Table 1

Demographic values

Conclusions In our study, it was shown that the effects of iNO on platelets could be monitored by BMI and MPV. Although it did not reach the limit of statistical significance, an increasing trend in platelet counts with iNO treatment was noteworthy.

  • Persistent pulmonary hypertension
  • Inhaled nitric oxide therapy
  • Platelet Values

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