Article Text
Abstract
Aim Continuous glucose monitors(CGMs) are becoming the standard of care for children with type 1 diabetes mellitus(T1DM), improving glycemic control and psychosocial outcome. Mostly due to economic reasons, CGMs weren’t available to every child with T1DM. Starting from January2023, our government resoluted to provide CGMs to children with Investigating CGMs’ impact on glycemic control in children with T1DM via evaluating change in HbA1c was aimed.
Material and Method 23 children(M/F: 10/13) diagnosed with T1DM (mean age:10.4∓3.8 (3–14.5) years) who have been using CGMs ≥6 months while receiving basal and bolus insulin injections were recruited. Children on partial remission, with comorbidities or non-compliant to CGM were excluded. Clinical and laboratory findings were evaluated prior to(using glucometer), 3 and 6 months after CGM utilization. Change in HbA1c (ΔHbA1c) was calculated by HbA1c at 6th month of CGM subtracted from last HbA1c using glucometer.
Results Prior to CGM, hospitalization due to diabetic ketoacidosis was 2 (0–4) times/year. CGM was initiated when 47.8% were pubertal (mean age:12.4∓4.3(4.1–16.6) years). Mean bodyweight, height, body mass index standard deviation score of patients prior to, and after 3 and 6 months of CGM remained the same (table 1) (p=0.076;0.091;0.085). Mean HbA1c prior to CGM was 11.2% ∓3.2 while it was 9.7% ∓2.5 at 3rd month, 8.4% ∓1.3 at 6th month (table 1). After 6 months of CGM utilization, decrease in HbA1c was significant (p=0.022). Prior to CGM, HbA1c was ≥8% in 65.2%, while it was in 34.7% after 6 months of CGM utilization(p=0.019). Change in HbA1c was more prominent in pubertal children than in prepubertal ones (4.3%∓1.9/2.2%∓1.1;p=0.023). Two children using CGM were admitted to the hospital due to diabetic ketoacidosis.
Conclusions Short-term CGM utilization in children with T1DM receiving insulin injections provide better glycemic control than blood glucose monitorization with glucometer, decrease hospital admissions due to diabetic ketoacidosis. Improvement in glycemic control is more prominent in adolescents.