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OP-144 Long-term neurodevelopmental effects of exclusively high cord lactate levels in term new-born
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  1. Aslan Yılmaz,
  2. Mehmet Vural
  1. Istanbul University Cerrahpasa Faculty of Medicine

Abstract

Aim This study was conducted to evaluate the effect of cord arterial blood gas analysis (ABGA) lactate level on long-term neurodevelopment of new-borns without any clinical signs of perinatal asphyxia

Material and Method Cases with a 5-minute Apgar score <7, sign of fetal distress in their antenatal follow-up were excluded. The cases (n=1438) were divided into two groups those with high cord lactate level (above 5 mmol/L, n=92) and those with low lactate level (below 2 mmol/L, n=255). An Ages & Stages Questionnaire, Third Edition (ASQ-3) developmental screening questionnaire was sent to all parents. Patients with a chronological age between 24–42 months and for whom the questionnaire was fulfilled by the parents (low lactate group, n=29, and high lactate group, n=45) were evaluated.

Results No difference was observed between two groups in terms of demographic characteristics such as age (p=0.1669), male gender (p=0.906), mother’s working situation (p=0.948), mother’s education level (p =0.828), father’s education level (p=0.507), and family’s total income (p=0.642). Mean ACQ-3 developmental screening test scores were significantly lower in the high lactate group compared to the low lactate group concerning; fine motor (40 vs. 60, p=0.001), problem-solving (50 vs. 60, p=0.002) and personal social development (45 vs. 60, p=0.003) (table 1). No difference was observed in terms of communication and gross motor total scores.

Abstract OP-144 Table 1

Comparison of the group with low and high umbilical cord lactate levels with an ACQ-3 development test

Conclusions We observed that cases with a normal 5-minute Apgar score, no suspected perinatal asphyxia, and a cord lactate value of ≥5 fell behind their peers when evaluated with the ACQ-3 developmental screening questionnaire.

  • Lactate
  • Cord blood gas
  • Apgar score
  • Term İnfant
  • Long-term outcomes.

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