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PP-022 Gene polymorphisms associated with obesity in adolescent girls
  1. Liudmila Firsova1,
  2. Nina Evdokimova1,
  3. Laura Shogiradze2,
  4. Alevtina Pokhlebkina3,
  5. Yurii Petrenko1,
  6. Elena Mikhnina4,
  7. Valeria Novikova1,
  8. Ruslan Glushakov6,
  9. Natalia Prokhorova6,
  10. Aleksandra Buntovskaya6,
  11. Aleksandra Trandina6,
  12. Vitaliy Bezhenar4
  1. 1‘St. Petersburg State Pediatric Medical University’, St. Petersburg, 194100, Litovskaya st. 2, Russia
  2. 2‘Children’s City Clinic No. 19’ St. Petersburg, 197046, Kuibysheva st. 25, Russia
  3. 3Multidisciplinary clinic ‘Scandinavia’, St. Petersburg, 197732, Ilyushina st. 4, building 1, Russia
  4. 4‘Pavlov First Saint Petersburg State Medical University’, St. Petersburg, 197022, Lev Tolstoy st. 6–8, Russia
  5. 5‘Ott Research Institute of Obstetrics, Gynecology and Reproductology’, St. Petersburg, 199034, Medeleevskaya line no. 3, Russia
  6. 6Department of medical and biological research of the Scientific research center ‘Kirov Military Medical Academy’, St. Petersburg, 194044, Academic Lebedev st. 6, Russia


Aim To study the prevalence of genotypes and alleles of the brain-derived neurotrophic factor gene (BDNF val66met), leptin receptor gene (LEPR Arg223Gln), fat mass and obesity-associated gene (FTO A23525T), angiotensinogen gene 1 (AGT Thr174Met), angiotensinogen gene 2 (AGT Met235Thr), fatty acid binding protein 2 gene (FABP2 Ala54Thr), and peroxisome proliferator-activated receptor gamma2 gene (PPARG2 Pro12Ala) in adolescent girls with obesity.

Material and Method A total of 72 adolescent girls aged 12–17 years were examined. Group 1 consisted of 36 children with obesity, and group 2 consisted of 36 children without obesity. Anthropometric, molecular genetics, and statistical methods were used.

Results In 80% of cases, they were carriers of the Pro allele of the PPARG2 gene, had higher BMI, and were at risk of developing type 2 diabetes. The presence of the BDNF Met/Met gene mutation was found in 14% of those surveyed, which is associated with the risk of developing neurodegenerative disorders. The allele A of the FTO gene was detected in 14% of cases. Physical activity plays an important role in combating obesity. The presence of the LEPR gene mutation was found in 28% of children, which determines the risk carbohydrate and lipid metabolism disorders, elevated blood pressure. Homozygous carriage of the AGT gene alleles (Thr174Met) and (Met235Thr) was detected in 11% and 4% of cases, respectively. Heterozygous carriage of alleles of these genes was found in 64% and 55% of cases. This indicates a high risk of developing arterial hypertension, ischemic heart disease, gestosis, and preeclampsia during pregnancy. The FABP2 gene mutation (Thr/Thr) and (Ala/Thr) was present in 8% and 77% of adolescents, respectively. Girls in this group should limit calorie intake from fats and maintain physical activity.

Conclusions Molecular genetic testing should be performed in adolescent girls with obesity.

  • obesity
  • molecular genetics

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