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PP-029 Multicenter study of vitamin D levels in children with chronic diseases in the Russian federation
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  1. Еlena Kondratyeva1,
  2. Elena Loshkova1,
  3. Nuriniso Odinaeva1,
  4. Elena Zhekaite1,
  5. Natalia Ilyenkova2,
  6. Leonid Klimov3,
  7. Yulia Melyanovskaya4,
  8. Yuri Mizernitsky5,
  9. Svetlana Dolbnya3
  1. 1Research Clinical Institute of Childhood of the Ministry of Health of the Moscow Region
  2. 2V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
  3. 3Stavropol State Medical University of the Ministry of Health of the Russian Federation
  4. 4Federal state budgetary scientific institution «Research Centre for Medical Genetics»
  5. 5NIKI Pediatrics GBOU VPO RNRMU im. N.I. Pirogov Ministry of Health of Russia, Moscow

Abstract

Aim To assess the frequency of low vitamin D levels and the level of calcidiol in patients with cystic fibrosis (CF), bronchial asthma (BA), juvenile idiopathic arthritis (JIA) in three regions of Russia.

Material and Method A total of 283 patients with CF, 160 with BA, 150 with JIA, and 333 healthy children in the control group were examined in three regions of the Russian Federation (Moscow region, Krasnoyarsk region, Stavropol region).

Results Normal concentration of 25(OH)D was detected in 49.3% of CF, insufficiency in 26.3%, deficiency in 16.7% of children, severe deficiency in 7.7% of patients. The maximum level of 25(OH)D was detected in the Moscow region (30.7 ng/ml), further in the Krasnoyarsk Territory (27.1 ng/ml), the minimum - in the Stavropol Territory (24.4 ng/ml). In the general group of patients with asthma, 89.62% had a low supply of vitamin D, severe deficiency 23.71%, deficiency 46.66%, insufficiency 19.25%. An analysis of the supply of vitamin D depending on the region of residence showed that a low supply of 25(OH)D is observed among 70.6% of patients with asthma in the Moscow region, 92.6% of patients in the Krasnoyarsk region and all patients with asthma in the Stavropol region. Insufficient supply of vitamin D was found in 76% of children with JIA, vitamin D deficiency was detected in 38.0% of cases, severe deficiency in 10.0%; deficiency in 28.0%. The frequency of low vitamin D levels in the regions did not differ significantly: Moscow region (73.9%), Krasnoyarsk region (73.0%), Stavropol region (73.1%), but the frequency of severe deficiency was significantly higher among patients in Krasnoyarsk ( 17.6%) and Stavropol (16.7%) compared to Moscow (4.3%).

Conclusions Low vitamin D supply was revealed among children with cystic fibrosis in 50.7%, asthma in 89.6%, juvenile idiopathic arthritis in 76.0% in three regions of Russia.

  • low vitamin D supply
  • calcidiol
  • cystic fibrosis
  • bronchial asthma
  • juvenile idiopathic arthritis

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