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PP-033 Effect of insulin-like growth factor 1 on the physical development of children with cystic fibrosis
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  1. Dilorom Akhmedova,
  2. Muzayyanakhon Alyaviya
  1. Tashkent Paediatric Medical Institute

Abstract

Aim To determine the effect of insulin-like growth factor-1 on the physical development of children with cystic fibrosis (CF).

Material and Method Studies were carried out to determine the physical development of children according to the standards of growth and development of children recommended by WHO and IGF-1 level in 40 children with CF aged 0 to 3 years. The patients were divided into three groups: Group 1 - 11 (27.5%) children with BAZ -2CO nutritional disorder, Group 2 - 14 (35.0%) children with BAZ -3CO nutritional disorder; Group 3 - 15 (37.5%) patients without nutritional disorder.

Results According to our study results, the mean level of insulin-like growth factor-1 in group 1 children was 23.45±5.5 ng/ml (with a norm of 60.0–350 ng/ml), in group 2 children - 28.2±8.4 ng/ml, and in group 3 without nutritional disorders - 133.0±28.1 ng/ml. Growth retardation is an important problem in children with CF, in group 2 -group according to HAZ parameters all children had severe growth retardation < -3SO. According to WAZ parameters, children with CF in groups 1–2 had moderate to severe weight deficiency (62.5%). In group 3, all children were within normal limits.

Conclusions IGF-1 level affects the physical development of the majority of children with CF (62.5%): the lower its level, the more pronounced the lag in growth and development of children. Determination of IGF-1 in children can be used as one of the criteria for evaluation and prognosis of development of children with CF.

  • cystic fibrosis
  • insulin-like growth factor-1
  • physical development of children

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