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PP-038 Role of enteral factor in the development of secondary hyperoxaluria
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  1. Magina Artikova,
  2. Alisher Sharipov
  1. Tashkent Pediatric Medical Institute

Abstract

Aim The aim of the research is to study risk factors and clinical and functional characteristics of secondary oxalate nephropathy in children to develop criteria for its early diagnosis.

Material and Method Materials:106 children with hyperoxaluria, of which in 76 cases secondary oxalate nephropathy was established (SON - main group) and 30 cases - calcium oxalate crystalluria (COC - control group). Methods: For works were work used general clinical, biochemical studies such as determination of the level of calcium, magnesium chloride, sodium, creatinine, urea, uric acid in blood serum, PCR, microbiological, ultrasound examination of the kidneys and bladder and statistical research methods.

Abstract PP-038 Table 1

Materials.

Results Results the establishment of dysbiotic disorders of the intestine in children with SON due to a sharp suppression of colonies of lacto- and bifidobacteria and a negative result of PCR diagnostics for the presence of Oxalobacter formigenes bacteria scientifically substantiate the role of the intestinal microbiota in the development of severe hyperoxaluria, leading to the enteric form of nephropathy (table 1).

Conclusions Discussion: Hyperoxaluria is a disease caused by metabolism disorder of oxalic acid and intestinal factors have significant influence on its progression. This disease can occur under the condition of excessive intake of oxalate and its precursors, increased intestinal absorption of oxalate and imbalance of intestinal flora, resulting in increased urine oxalate and calcium oxalate crystal, which lead to hematuria, proteinuria, recurrent kidney stones and nephrocalcinosis. Some patients may further progress to the AKI and CKD. With progressive decline in renal function, oxalate is reduced and deposits in the body can affect other tissues and organs. And adjustment of enteral factors is helpful for the treatment of hyperoxaluria. Conclusion Under the condition of excessive intake of oxalate and its precursors, increased intestinal absorption of oxalate, resulting in increased urine oxalate and calcium oxalate crystal, which lead to hematuria, proteinuria, recurrent kidney stones and nephrocalcinosis.

  • Enteral hyperoxaluria
  • oxalobacter formigenes
  • oxalate nephropathy
  • hyperoxaluria
  • children

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