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PP-040 Proteinuria/Nephrotic syndrome due to congenital cytomegalovirus (CMV)infection. Literature review and report
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  1. Abdulkarim Almakadma
  1. Alfaisal University

Abstract

Aim What is known: Cytomegalovirus congenital infection is the most common cause of congenital infections worldwide. It can cause mental retardation, loss of hearing and vision, and motor deficits. It is uncommon for CMV infection to present with nephrotic syndrome or significant proteinuria in pediatrics What is new: CMV infection might be the culprit for some cases of nephrotic syndrome in the pediatric population. it should be one of the differentials to consider when infants present with nephrotic syndrome because targeted therapy for the organism is available. •However, not all patients who have congenital CMV infection develop renal insult; we hypothesize that the reason for this selective damage by CMV in only specific cases may be due to genetic susceptibility such as mutated podocin genes.

Material and Method We review the available literature for cases of proteinuria in infancy due to CMV infection, and we report the case of a five-month-old female infant who presented to our center with severe edema and respiratory distress.

Results A five-month-old female infant who presented to our center with severe edema and respiratory distress. Serum albumin levels were very low, and spilling of albumin in the urine was significant. CMV PCR was significant in blood, urine, and bronchoalveolar lavage samples. Renal biopsy showed changes consistent with nephrotic syndrome. Ganciclovir was started, and the patient showed improvement.

Conclusions Based on our observation, we suggest that CMV infection might be the culprit for some cases of nephrotic syndrome in the pediatric population.it should be one of the differentials to consider when infants present with nephrotic syndrome because targeted therapy for the organism is available. not all patients who have congenital CMV infection develop renal insult; we hypothesize that the reason for this selective damage by CMV in only specific cases may be due to genetic susceptibility such as mutated podocin genes.

  • CMV
  • Proteinuria
  • Nephrotic syndrome
  • Congenital Infection.
  • Infant

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