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PP-059 Hemolytic anemia in children
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  1. Singer Cristina Elena1,
  2. Cosoveanu Carmen Simona1,
  3. Singer Maria2,
  4. Popescu Mihaela3,
  5. Popescu Alin4,
  6. Geormaneanu Cristina5
  1. 1University of Medicine and Pharmacy Craiova, 2nd Pediatric Clinic, Emergency County Hospital Craiova, Craiova, Romania
  2. 2resident doctor, Bucharest Military Hospital, Romania
  3. 3Endocrinology Clinic, University of Medicine and Pharmacy in Craiova, Romania
  4. 4Medical Clinic, University of Medicine and Pharmacy in Craiova, Romania
  5. 5Emergency Department, University of Medicine and Pharmacy in Craiova, Romania

Abstract

Aim Hemolytic anemia is a condition that involves the destruction of erythrocytes (hemolysis) faster than the bone marrow could produce them.

Material and Method The study was carried out between 01.01.2018–01.01.2023 in children 0–18 years hospitalized with hemolytic anemia.

Results 40 children with hemolytic anemia were hospitalized: 11 (27.5%) with thalassemia major, 3 (7.5%) with thalassemia intermedia, 8 (20%) with thalassemia minor, 6 (15%) with microspherocytosis, 5 (12.5%) with G6PD deficiency, 6 (15%) with autoimmune hemolytic anemia and 1 (2.5%) with paroxysmal nocturnal hemoglobinuria. Distribution on sex: female 23 (57.5%) and male 17 (42.5%), by environment: 22 (55%) from rural and 18 (45%) from urban. Clinical manifestations: paleness with icterus, splenomegaly, dark urine, abdominal pain, asthenia. Average value of hemoglobin at admission at children with thalassemia major: 3.81±1.04 (3.3–4.2) g%, thalassemia intermedia: 6.15±1.64 (4.4–9.2) g%, thalassemia minor: 7.21±0.81 (4.4–8.2) g%, microspherocytosis: 6.77±2.15 (3.9–9.5) g%, G6PD deficiency: 6.78±2.85 (3.1–10.4) g%, autoimmune hemolytic anemia: 5.53±1.52 (3.11–7.8) g%, paroxysmal nocturnal hemoglobinuria 5.25±1.64 (3.6–6.9) g%. All children had increased values of bilirubin, sideremia, and ferritin.

Conclusions The most common hemolytic anemia was thalassemia major (27.5%). Most of them came from rural areas, and the female gender was more frequent. The lowest mean value of hemoglobin was in those with thalassemia major.

  • hemolytic anemia
  • clinical manifestation
  • children

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