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PP-071 Clinical features and parameters of cytokine profile in children with influenza
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  1. Ekaterina Kazantseva,
  2. Alla Petrova,
  3. Marina Darenskaya,
  4. Lyubov Rychkova,
  5. Natalia Semenova,
  6. Leonid Sholokhov
  1. Federal State Budgetary Institution «Scientific Centre for Family Health and Human Reproduction Problems»

Abstract

Aim To analyze clinical parameters and cytokine profile in children with influenza.

Material and Method A prospective comparative study was conducted with the participation of 50 children aged 1 month to 11 years old diagnosed with influenza (the study group), who were treated as inpatients at the Irkutsk Regional Infectious Diseases Clinical Hospital from 2018 to 2019. The diagnosis of influenza was verified by the polymerase chain reaction (PCR). The concentration of cytokines and C-reactive protein (CRP) were determined using the enzyme-linked immunosorbent assay (ELISA). The control group consisted of healthy children (n = 50, average age 5.3 ± 2.6). A statistical package was used - STATISTICA 10.0 Stat-Soft Inc, USA.

Results In the study group, 52% (n=26) were boys, and 48% (n=26) were girls (median age was 3 ± 2.6 years). The A (H1N1sw2009) was a dominant serotype of the etiological structure of influenza since it accounted for 76% (n=38) of cases. Influenza complications included ketoacidosis that occurred in 12% (n=6) cases, pneumonia - 16% (n=8) cases, acute obstructive bronchitis - 2% (n=1) cases. In children with influenza, mucous runny nose was predominated over pyogenic runny nose (72%, n = 36) with manifestations of 5.0 ± 2.48 days, dry cough - 84% (n=42) and wet cough - 6% (n=3). The median fever was 38.5 ± 0.68 °C, the duration of fever was 2.0 ± 1.45 days. In the age group of 7–11 years, a significant increase in levels of serum IL-1β (14.50 pg/ml), IL-8 (247 pg/ml) and IFN-a (45.75 pg/ml) was found [figure 1]. In influenza complicated by pneumonia, a direct correlation was noted between the level of CRP and IL-4, so these indicators may reflect the severity of clinical manifestations.

Abstract PP-071 Figure 1

Interleukin levels in children 7–11 years old (n=14)

Conclusions Influenza in children is characterized by a typical course with increased levels of pro-inflammatory cytokines. Influenza complicated by pneumonia, is characterized by Th2 immune response.

  • children
  • clinic
  • cytokines
  • influenza

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