RT Journal Article SR Electronic T1 Arterial flow patterns in healthy transitioning near-term neonates JF BMJ Paediatrics Open FD BMJ Publishing Group Ltd SP e000333 DO 10.1136/bmjpo-2018-000333 VO 3 IS 1 A1 Stritzke, Amelie A1 Murthy, Prashanth A1 Kaur, Sharandeep A1 Kuret, Verena A1 Liang, Zhiying A1 Howell, Sarah A1 Tyberg, John V YR 2019 UL http://bmjpaedsopen.bmj.com/content/3/1/e000333.abstract AB Objective Significant haemodynamic changes occur at delivery impacting organ blood flow distribution. We aimed to characterise Doppler indices patterns over time in three different organs (brain, gut and kidney) and test them as measures of vascular resistance.Design Observational cohort study. Serial Doppler interrogations of the anterior cerebral, superior mesenteric and renal arteries within 2 hours, 2–6, and 24 hours of life, in combination with central haemodynamic data.Patients Healthy, near-term (>36 weeks of gestation) neonates.Outcome measures Pulsatility (PI) and Resistance Indices (RI) patterns and organ-specific conductances, detailed echocardiographic haemodynamic measures.Results Twenty-one babies were studied. Doppler morphology and adaptation patterns were distinctly different between the organs (brain, gut and kidney) supporting autonomous vascular regulatory effects. The PI differentiated especially between kidney and other organ flow consistently over time. PI and RI for all three organs decreased. The variance in organ conductance did not explain the variance in 1/PI, indicating that PI is not a measure of resistance. Superior mesenteric artery had the highest velocity with 72 cm/s. Non-invasively acquired pilot serial values in a normal population are given. Patent ductus arteriosus flow remained open at discharge for 36%.Conclusions Haemodynamic transitioning patterns assessed by serial Dopplers in healthy near-term neonates differ in brain, gut and kidney: Doppler waveform morphology differs, and PI differentiates renal Doppler morphology, compared with the other organs. While PI and RI decline for all organs, they do not measure resistance. Brain artery velocity increases, mesenteric perfusion is variable and renal Vmax decreases.