TY - JOUR T1 - Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan JF - BMJ Paediatrics Open JO - BMJ Paediatrics Open DO - 10.1136/bmjpo-2018-000414 VL - 3 IS - 1 SP - e000414 AU - Takako Takano AU - Michio Akagi AU - Haruyoshi Takaki AU - Ryo Inuzuka AU - Yoshitsugu Nogimori AU - Hiroshi Ono AU - Masahide Kaneko AU - Norifumi Hagiwara Y1 - 2019/06/01 UR - http://bmjpaedsopen.bmj.com/content/3/1/e000414.abstract N2 - Reports indicate lower Down syndrome (DS) survival among females than among males in Australia, contrasting with female longevity in the general population. Using data on 1310 people with DS (626 females and 684 males) in Japan from five hospitals’ medical records and questionnaires completed by parents of people with DS, we investigated sex differences in congenital heart disease (CHD), which may be related to mortality. The CHD rate was significantly higher for females (354, 57%) than for males (338, 49%; p=0.010). Significantly more females (199, 32%) than males (175, 26%) underwent surgery for CHD (p=0.018). ER -