RT Journal Article
SR Electronic
T1 Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan
JF BMJ Paediatrics Open
JO BMJ Paediatrics Open
FD BMJ Publishing Group Ltd
SP e000414
DO 10.1136/bmjpo-2018-000414
VO 3
IS 1
A1 Takako Takano
A1 Michio Akagi
A1 Haruyoshi Takaki
A1 Ryo Inuzuka
A1 Yoshitsugu Nogimori
A1 Hiroshi Ono
A1 Masahide Kaneko
A1 Norifumi Hagiwara
YR 2019
UL http://bmjpaedsopen.bmj.com/content/3/1/e000414.abstract
AB Reports indicate lower Down syndrome (DS) survival among females than among males in Australia, contrasting with female longevity in the general population. Using data on 1310 people with DS (626 females and 684 males) in Japan from five hospitals’ medical records and questionnaires completed by parents of people with DS, we investigated sex differences in congenital heart disease (CHD), which may be related to mortality. The CHD rate was significantly higher for females (354, 57%) than for males (338, 49%; p=0.010). Significantly more females (199, 32%) than males (175, 26%) underwent surgery for CHD (p=0.018).