RT Journal Article
SR Electronic
T1 Plasma citrate concentration: a possible biomarker for glaucoma in children
JF BMJ Paediatrics Open
FD BMJ Publishing Group Ltd
SP e000023
DO 10.1136/bmjpo-2017-000023
VO 1
IS 1
A1 Marta Michalczuk
A1 Porowski Tadeusz
A1 Beata Urban
A1 Wasilewska Anna
A1 Alina Bakunowicz- Łazarczyk
YR 2017
UL http://bmjpaedsopen.bmj.com/content/1/1/e000023.abstract
AB Objectives The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis.Patients 34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study group and 34 patients with no ophthalmological ailments were qualified for the control group (mean age 16.1±1.98 years). Plasma and urine citrate levels in the study and the control group (Kruskal-Wallis test) were compared.Results Plasma citrate levels in the study (16.33±4.51 mg/L) and the control group (19.11±3.66 mg/L) were different; the statistical significance (p=0.0036). Plasma citrate concentrations were significantly lower in the study group in comparison with the control group. There were no statistically important differences between the study group (291.12±259.13 mg/24 hours; 275.82±217.57 mg/g) and the control group (434.88±357.66 mg/24 hours; 329.81±383.27 mg/g) including urine citrate level (p=0.052) and urine citrate to creatine ratio (p=0.4667).Conclusion Plasma citrate concentration might be considered as glaucoma biomarker in paediatric population.