RT Journal Article
SR Electronic
T1 Physiological responses to cuddling babies with hypoxic–ischaemic encephalopathy during therapeutic hypothermia: an observational study
JF BMJ Paediatrics Open
JO BMJ Paediatrics Open
FD BMJ Publishing Group Ltd
SP e001280
DO 10.1136/bmjpo-2021-001280
VO 5
IS 1
A1 David Odd
A1 Satomi Okano
A1 Jenny Ingram
A1 Peter S Blair
A1 Amiel Billietop
A1 Peter J Fleming
A1 Marianne Thoresen
A1 Ela Chakkarapani
YR 2021
UL http://bmjpaedsopen.bmj.com/content/5/1/e001280.abstract
AB Objectives To determine whether parents cuddling infants during therapeutic hypothermia (TH) would affect cooling therapy, cardiorespiratory or neurophysiological measures. The secondary aim was to explore parent–infant bonding, maternal postnatal depression and breastfeeding.Design Prospective observational study.Setting Two tertiary neonatal intensive care units (NICU).Participants Parents and their term-born infants (n=27) receiving TH and intensive care for neonatal hypoxic–ischaemic encephalopathy.Interventions Cuddling up to 2 hours during TH using a standard operating procedure developed in the study (CoolCuddle).Main outcome measures Mean difference in temperature, cardiorespiratory and neurophysiological variables before, during and after the cuddle. Secondary outcomes were parental bonding, maternal postnatal depression and breastfeeding.Results During 70 CoolCuddles (115 cumulative hours), there were measurable increases in rectal temperature (0.07°C (0.03 to 0.10)) and upper margin of amplitude-integrated electroencephalogram (1.80 µV (0.83 to 2.72)) and decreases in oxygen saturations (−0.57% (−1.08 to −0.05)) compared with the precuddle period. After the cuddle, there was an increase in end-tidal CO2 (0.25 kPa (95% CI 0.14 to 0.35)) and mean blood pressure (4.09 mm Hg (95% CI 0.96 to 7.21)) compared with the precuddle period. From discharge to 8 weeks postpartum, maternal postnatal depression declined (13 (56.5%) vs 5 (23.8%), p=0.007); breastfeeding rate differed (71% vs 50%, p=0.043), but was higher than national average at discharge (70% vs 54.6%) and mother–infant bonding (median (IQR): 3 (0–6) vs 3 (1–4)) remained stable.Conclusion In this small study, CoolCuddle was associated with clinically non-significant, but measurable, changes in temperature, cardiorespiration and neurophysiology. No infant met the criteria to stop the cuddles or had any predefined adverse events. CoolCuddle may improve breastfeeding and requires investigation in different NICU settings.Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information. Data for supplementary material will be available as deidentified individual participant data following necessary regulatory approvals.