RT Journal Article SR Electronic T1 OP-085 Neonatal intensive care health service-associated infection surveillance central venous catheter-associated bloodstream infection JF BMJ Paediatrics Open JO BMJ Paediatrics Open FD BMJ Publishing Group Ltd SP A40 OP A40 DO 10.1136/bmjpo-2024-EPAC.84 VO 8 IS Suppl 5 A1 Unkar, Zeynep Alp A1 Pınar, Eymen A1 Ulu, Ersin A1 Vural, Mehmet YR 2024 UL http://bmjpaedsopen.bmj.com/content/8/Suppl_5/A40.1.abstract AB Aim The survival of low birth weight premature infants and their prolonged follow-up in Neonatal Intensive Care Units (NICUs) pose various risks. The use of invasive devices and the prevalence of hospital-acquired infections requiring broad-spectrum antibiotics in neonatal intensive care units range from 9.3% to 25%. It is essential to identify infectious agents through surveillance studies conducted by the Hospital Infection Control Committee (HICC).Material and Method The Hospital Infection Control Committee (HICC) conducted Healthcare-Associated Infection (HAI) surveillance in the Neonatal Intensive Care Unit (NICU) from 2021 to 2023. Using the ’Ministry of Health National Healthcare-Associated Infections Surveillance Guide (2017),’ data for 2021–2022 was presented in four periods, and 2023 data in the 1st and 2nd periods, classified by incidence density, infection rates, invasive device-associated infections, device usage rates, and causative agent distribution.Results In 2021, with 250 patient admissions and an infection rate of 19%, the incidence density was 12.2. Infants weighing less than 750 grams had a 24% Central Venous Catheter-Associated Bloodstream Infection rate, decreasing with weight. Despite a high density of 18.6 in the 1st period, with Introducing a checklist created by the HICC team to ensure adherence to infection control measures during the placement of CVC/PICC/SVC it significantly decreased in the 2nd period to 8.5. In 2022, adherence to protocols led to a 25% decrease. In 2023, improvements in protocols led to decreased CVC infections, aligning with national averages, especially for infants weighing under 1000 grams.Conclusions SVC-Related Bloodstream Infection density for all weight categories decreased from 12.1 in 2021 to 6.1 in 2022 and further to 6.2 in the first 6 months of 2023. This decline indicates a reduction in infection density compared to the previous period. Implementing a Active surveillance system is key to achieving a significant reduction or complete prevention of hospital infections.