Table 5

Reporting of adverse events and harm-related endpoints stratified by the nature of the intervention

Nature of the interventionNReported data on adverse events, N (%)P valueReported data on harm-related endpoints, N (%)P value
Yes
143 (48)
No
157 (52)
Yes
215 (72)
No
85 (28)
Data monitoring committee
 Reported5543 (78)12 (22)<0.00152 (95)3 (6)<0.001
 Not reported245100 (41)145 (59)163 (67)82 (34)
Nature of the intervention
 Drug8570 (82)15 (18)<0.00169 (81)16 (19)0.002
 Vaccine1412 (86)2 (14)14 (100)0 (0)
 Rehabilitation or psychosocial304 (13)26 (87)20 (67)10 (33)
 Prevention or screening145 (36)9 (64)8 (57)6 (43)
 Surgery or radiotherapy95 (56)4 (44)6 (67)3 (33)
 Communication, organisational or educational524 (8)48 (92)28 (54)24 (46)
 Alternative therapeutic149 (64)5 (36)8 (57)6 (43)
 Device2916 (55)13 (45)20 (69)9 (31)
 Other*5318 (34)35 (66)42 (79)11 (21)
  • *Included therapeutic nutritional interventions (eg, supplements, infant formula and probiotics), sensorimotor interventions, physical activity interventions and financial interventions.