Comparison of HRQOL scores of functional class categories of CHD with controls
| Scale | Functional class categories* | ||||
| Acyanotic CHD | Cyanotic CHD | P values | |||
| LRS (1) | DPB (2) | IPB (3) | SVP (4) | ||
| AMD (99% CI) | AMD (99% CI) | AMD (99% CI) | AMD (99% CI) | ||
| Generic scores scales child report | |||||
| Total scale score | −13.1 | −21.7 | −28.3 | −25.3 | (1)<0.001, (2)<0.001 |
| (−17.9 to −8.2) | (−32.9 to −10.6) | (−48.6 to −7.9) | (−30.7 to −19.9) | (3)<0.001, (4)<0.001 | |
| Physical health summary | −15.6 | −31 | −40.6 | −31.3 | (1)<0.001, (2)<0.001 |
| (−21.9 to −9.3) | (−40.3 to −21.7) | (−62.1 to −19.2) | (−39.7 to −22.8) | (3)<0.001, (4)<0.001 | |
| Psychosocial health summary | −13.7 | −17.3 | −17.3 | −20.5 | (1)<0.001, (2)<0.001 |
| (−22.0 to −5.4) | (−27.1 to −7.5) | (−37.5 to 2.9) | (−25.2 to −15.8) | (3) 0.027, (4)<0.001 | |
| Emotional functioning | −9.6 | −7.5 | −10 | −14.4 | (1)<0.001, (2) 0.192 |
| (−16.4 to −2.8) | (−22.3 to 7.3) | (−37.4 to 17.4) | (−24.2 to −4.6) | (3) 0.347, (4)<0.001 | |
| Social functioning | −20 | −20 | −10 | −20 | (1)<0.001, (2)<0.001 |
| (−20.0 to −20.0) | (−20.0 to −20.0) | (−10.0 to −10.0) | (−20.0 to −20.0) | (3)<0.001 (4)<0.001 | |
| School functioning | −15 | −20 | −10 | −25 | (1)<0.001, (2)<0.001 |
| (−24.9 to −5.1) | (−29.0 to −11.0) | (−26.8 to 6.8) | (−37.1 to −12.9) | (3) 0.125, (4)<0.001 | |
| Generic scores scales parent report | |||||
| Total scale score | −9.4 | −28.7 | −17.4 | −16.3 | (1)<0.001, (2)<0.001 |
| (−13.5 to −5.3) | (−35.6 to −21.7) | (−29.8 to −5.0) | (−26.4 to −6.2) | (3)<0.001, (4)<0.001 | |
| Physical health summary | −12.5 | −34.4 | −28.1 | −31.3 | (1)<0.001, (2)<0.001 |
| (−14.9 to −10.1) | (−35.8 to −32.9) | (−38.9 to −17.4) | (−35.1 to −27.4) | (3)<0.001, (4)<0.001 | |
| Psychosocial health summary | −7.1 | −18.2 | −7.4 | −10.4 | (1)<0.001, (2)<0.001 |
| (−11.1 to −3.0) | (−24.6 to −11.9) | (−28.2 to 13.3) | (−16.3 to −4.5) | (3) 0.357, (4)<0.001 | |
| Emotional functioning | −2.5 | −13.8 | 1.3 | −7.5 | (1) 0.323, (2)<0.001 |
| (−9.0 to 4.0) | (−20.4 to −7.1) | (−36.0 to 38.5) | (−20.9 to 5.9) | (3) 0.931, (4) 0.150 | |
| Social functioning | 0 | −10 | 0 | −10 | (1) 1.000, (2)<0.001 |
| (0.0 to 0.0) | (−10.0 to −10.0) | (0.0 to 0.0) | (−10.0 to −10.0) | (3) 1.000, (4)<0.001 | |
| School functioning | −15 | −33.3 | −10 | −15 | (1)<0.001, (2)<0.001 |
| (−21.8 to −8.2) | (−44.2 to −22.4) | (−28.4 to 8.4) | (−24.3 to −5.7) | (3) 0.161, (4)<0.001 | |
*Functional class LSOL (left-sided obstructive lesions) was excluded from the subgroup analysis as the numbers were less in this group.
AMD, adjusted median difference; CHD, congenital heart disease; DPB, decreased pulmonary blood flow; HRQOL, health-related quality of life; IPB, increased pulmonary blood flow; LRS, left to right shunts; SVP, single ventricle physiology.