Table 6

Comparison of cardiac scores between functional class categories of CHD*

ScaleFunctional class categories†
Acyanotic CHDCyanotic CHDP values
DPB (1)IPB (2)SVP (3)
AMD (99% CI)AMD (99% CI)AMD (99% CI)
Cardiac scales child report
Heart problems−17.9 (−33.4 to −2.3)−14.3 (−49.6 to 21.0)−17.3 (−34.2 to −0.4)(1) 0.003, (2) 0.293, (3) 0.009
Treatment0.0 (−11.9 to 11.9)−15.0 (−54.2 to 24.2)2.5 (−8.5 to13.5)(1) 1.000, (2) 0.315, (3) 0.550
Physical appearance−4.2 (−17.5 to −9.2)−20.8 (−47.8 to 6.2)−4.2 (−14.9 to 6.5)(1) 0.418, (2) 0.046, (3) 0.311
Anxiety0.0 (−18.1 to 18.1)−6.3 (−38.6 to 26.1)−6.3 (−27.2 to 14.7)(1) 1.000, (2) 0.615, (3) 0.437
Cognitive problems−16.7 (−28.4 to −4.9)0.0 (−16.5 to 16.5)−16.7 (−27.4 to −5.9)(1)<0.001, (2) 1.000, (3)<0.001
Communication−2.8 (−19.0 to 13.5)2.8 (−18.8 to 24.4)2.8 (−12.2 to 17.8)(1) 0.657, (2) 0.737, (3) 0.629
Cardiac scales parent report
Heart problems−21.4 (−32.6 to −10.2)−3.5 (−34.7 to 27.5)−21.4 (−33.4 to −9.4)(1)<0.001, (2) 0.766, (3)<0.001
Treatment−4.3 (−22.0 to 13.3)−7.7 (−39.9 to 24.6)0.7 (−12.4 to 13.7)(1) 0.523, (2) 0.536, (3) 0.894
Physical appearance0.0 (−1.9 to 1.9)0.0 (−10.8 to 10.8)0.0 (−3.3 to 3.3)(1) 1.000, (2) 1.000, (3) 1.000
Anxiety−12.5 (−26.5 to 1.5)−12.5 (−48.1 to 23.1)0.0 (−19.0 to 19.0)(1) 0.022, (2) 0.363, (3) 1.000
Cognitive problems0.0 (−3.8 to 3.8)0.0 (−17.7 to 17.7)−8.3 (−15.6 to −1.1)(1) 1.000, (2) 1.000, (3) 0.003
Communication−10.0 (−27.4 to 7.4)−10.0 (−36.9 to 16.9)−16.7 (−34.5 to 1.2)(1) 0.138, (2) 0.334, (3) 0.016
  • *With left to right shunts (LRS) as reference.

  • †Functional class LSOL (left-sided obstructive lesions) was excluded from the subgroup analysis as the numbers were less in this group.

  • AMD, adjusted median difference; CHD, congenital heart disease; DPB, decreased pulmonary blood flow; IPB, increased pulmonary blood flow; SVP, single ventricle physiology.