Table 2

Results at 12 and 24 hours

Hypotonic groupIsotonic groupP value
Patients with mild hyponatraemia (Na <135) at 12 hours29/154 (18.8%)12/145 (8.2%)<0.01*
Patients with mild hyponatraemia (Na <135) at 24 hours66/154 (42.8%)18/145 (12.4%)<0.01*
Patients with moderate hyponatraemia (Na <130) at 12 hours0/1540/145
Patients with moderate hyponatraemia (Na <130) at 24 hours5/154 (3.2%)0/145
Patients with metabolic acidosis (pH <7.30) at 12 hours18/154 (11.6%)26/145 (17.9%)0.32*
Patients with metabolic acidosis (pH <7.30) at 24 hours32/154 (20.7%)38/145 (26.2%)0.71*
Sodium serum (mEq/L) at 12 hours†136.3 (133–139)140.1 (138–142)0.02‡
Sodium serum (mEq/L) at 24 hours†134.4 (128–139)139.3 (136–142)0.03‡
pH in blood at 12 hours†7.36 (7.31–7.42)7.34 (7.27–7.40)0.18‡
pH in blood at 24 hours†7.39 (7.35–7.40)7.36 (7.29–7.39)0.31‡
Serum bicarbonate (mmol/L) at 12 hours†23 (21–31)24 (19–28)0.23‡
Serum bicarbonate (mmol/L) at 24 hours†28 (24–33)25 (22–31)0.19‡

  • Categorical variables are expressed as percentages.

  • *χ2 test.

  • †Median, IQR (25–75).

  • ‡Wilcoxon test.

  • Na, sodium.