Table 4

Blood pressure and heart rate adverse effects for studies with p values, percentage change from baseline

PaperRegimenmBP (mm Hg) ±SDmDBP (mm Hg) ±SDmSBP (mm Hg) ±SDmHR (beats/min)±SD
Bonthala (2000)8P 1%, C 0.2% (2 d)↓ 11.5±5.8%*↑ 0.6±1.2%*
Bolt (1992)7
P 2.5% (1d), T 0.5% (2 d)↓ 4%↓ 1%
C 0.5% (1d), T 0.5% (2 d)↑ 5.1%*↑ 3.7%†
Elibol (1997)17




C 1% (2 d)↑ 16.2%±2.2%*†
C 1% (2 microd)↓ 1%±2.3%*†
P 10% (2 d)↑ 8%±0.2%*†
P 10% (2 microd)0±1.9%*
T 0.5% (2 d)↑ 17.5%±0.2%*†
T 0.5% (2 microd)↓ 1.4 ± 0.3%*
Isenberg (1984 March)40

C 0.5% (2 d)↓10%±12%†↑ 7.5%±18%
C 0.5%, T 0.5% (2 d)↓ 10%±12%†↑ 7.5%±18%
P 1%, C 0.2% (2 d)↓ 5.8%±14%†↓ 1.7%±11%
Isenberg (1984 July)18

C 0.5%↓ 13.2%↓ 3.3%
P 1%, C 0.2%↓ 3.8%↓ 4.3%
P 2.5%, T 0.5%↑ 19.6%↓ 5.2%
Jiang (2016)10P 0.5%, T 0.5% (3 d)↑ 8.5*†↑ 5.4%*§
Khoo (2000)16
P 1%, C 0.2% (3 d)↑ 3.7%−1%↑ 0.8%↓ 4.5%
P 2.5%, T 0.5% (3 d)↓ 0.4%↓ 0.3%↓ 1.2%↓ 6.6%
Laws (1996)11P 2.5% (2d), C 0.5% (4 d)↑ 4.8%*↑ 5%*↓ 1.3%*
Lees (1981)12P 2.5%, T 0.5% (1 d)↑ 19.4%†↑ 19.1%†↑ 17.1%†0%
Merritt (1981)45
P 2.5%, T 1% (3 d)0%
P 2.5%, T 0.5%,
C 0.5% (3 d)
0%
Phamonvaechavan (2012)23P 2.5%, T 0.75% (2 d)0%0%↓ 3.2%
Sindel (1986)19

P 2.5%, T 1% (2 d)↓ 17.1%±10.4%†
P 2.5%, T 0.5%,
C 0.5% (2 d)
↑ 22.8%±17.4%†↑ 10.0%±10.6%†
P 1%, T 1% (2 d)↑ 7.7%±9.3%†
  • *Data approximated from graph or was converted to percentage.

  • †P<0.05 to 0.01.

  • ‡Data not presented.

  • §P=0.08.

  • C, cyclopentolate;P, phenylephrine;T, tropicamide;d, standard drop;mDBP, mean diastolic blood pressure;mHR, mean heart rate;mSDP, mean systolic blood pressure;microd, microdrop.