Table 8

Publications providing data on respiratory adverse effects

PaperRegimenAdverse effect
Alshafei (2017)6P 2.5%, T 0.5% (3 d)No adverse effect on oxygen saturation, not statistically significant
Jiang (2016)10P 0.5%, T 0.5% (3 d)Apnoea: statistically significant increase (p<0.05).
Mitchell (2016)28P 1%, C 0.2% (3 d)Desaturations more likely in oxygen therapy group (p=0.01)
Mirmanesh (1992)22P 2.5% (3 d)Infants with BPD;
  • Reduction in mean pulmonary compliance (p<0.03)

  • Increased mean total resistance (p<0.01)

  • Reduced expiratory airflow (p<0.03)

Punyawattanporn (2009)41Not identifiedApnoea: one infant.
  • C, cyclopentolate;P, phenylephrine;T, tropicamide; d, standard drop.