Table 7

Summary of significant gastrointestinal events

PaperRegimenNEC and deathNECOther
CARM (2014)31 P 2.5%, C 0.5% (3 d)1
Ozgun (2014)29 P 1.25%, C 0.5% (2 d)1Abdominal distention (1)
Siu (2011)30 P 2.5%, C 1% (2 d)11Abdominal distension (1)
Milk intolerance (1)
Pneumatosis intestinalis (1)
CARM (2002)35 P 1%, C 0.5% (1 d)Abdominal distention (1)
Degrimencioglu (2014)50 P 2.5%, T 0.5% (3 d)Feed intolerance (1)
Abdominal distension (1)
Transient ileus (1)
Socarras (2017)48 P 2.5%, T(unknown%) (2 d)Feed intolerance (1)
Abdominal distension (1)
Sarici (2001)51 P 2.5%, C 0.5% (2 d)Vomiting (1)
Abdominal distention (1)
Gastric dilation (1)
Lim (2003)52 P 1%, C 0.2% (3 d)Abdominal distention (1)
Transient ileus (1)
Lim (2003)52 P 1%, C 0.2% (3 d)Transient ileus (1)
  • C, cyclopentolate;CARM, Centre for Adverse Reactions Monitoring; NEC, necrotising enterocolitis;P, phenylephrine;T, tropicamide;d, standard drop.