Characteristics of patients with neurodevelopmental assessment at 18 months of age
| Early TH n=36 | Late TH n=28 | P value | |
| C-section, n (%) | 24 (66.6) | 12 (42.9) | 0.1 |
| Male sex, n (%) | 19 (52.8) | 19 (67.9) | 0.2 |
| Gestational age (weeks), mean (SD) | 39 (1.6) | 39.2 (1.5) | 0.6 |
| Birth weight (kg), mean (SD) | 3.4 (0.71) | 3.4 (0.43) | 0.9 |
| Resuscitation score, median (IQR) | 5 (5–5) | 4 (4–5) | 0.0008 |
| Apgar score at 10 min, median (IQR) | 4.5 (3–6) | 5 (4–7) | 0.3 |
| Arterial cord blood pH, mean (SD) | 6.9 (0.1) | 6.9 (0.2) | 0.2 |
| Who initiated TH? | <0.0001 | ||
| Centre before advice, n (%) | 15 (41.7) | 1 (3.6) | |
| Centre after advice, n (%) | 16 (44.4) | 8 (28.6) | |
| Transport team, n (%) | 4 (11.1) | 14 (50) | |
| NICU, n (%) | 1 (2.8) | 5 (17.9) | |
| Time of referral to CHEO (hours), median (IQR) | 1.5 (0.9–2) | 2 (1.4–4.1) | 0.007 |
| Time of arrival of transport team, median (IQR) | 2.4 (1.8–3.3) | 4.4 (2.9–5.9) | 0.0003 |
| Time of initiation of TH, median (IQR) | 1.4 (0.7–2) | 4.4 (3.9–6.5) | <0.0001 |
| Time to target temperature, median (IQR) | 4.7 (3.4–6.5) | 7.9 (6.7–9) | 0.05 |
| Degree of encephalopathy before TH | 0.07 | ||
| Normal or Sarnat 1, n (%) | 11 (30.5) | 10 (35.7) | |
| Sarnat 2, n (%) | 18 (50) | 18 (64.3) | |
| Sarnat 3, n (%) | 7 (19.4) | 0 | |
| Abnormal cerebral function monitoring* | 0.2 | ||
| Discontinuous | 5 (17.2) | 4 (16.7) | |
| Burst suppression | 4 (13.8) | 6 (25) | |
| Low amplitude or flat trace | 3 (10.3) | 0 | |
| Seizures | 16 (44.4) | 14 (50) | 0.7 |
*Cerebral Function Monitoring performed in 29 patients in early TH with neurodevelopmental assessment at 18 months and 24 patients in late TH with neurodevelopmental assessment at 18 months.
CHEO, Children’s Hospital of Eastern Ontario; C-section, caesarean section; NICU, neonatal intensive care unit; TH, therapeutic hypothermia.