MRI findings in patients with neurodevelopmental assessment at 18 months of age, stratified by timing of therapeutic hypothermia
| Early TH n=36 (%) | Late TH n=28 (%) | P value | |
| Severity of injury according to NICHD scoring | 0.9 | ||
| 0 or 1A or 1B | 28 (77.7) | 22 (78.6) | |
| ≥2A | 8 (22.2) | 6 (21.4) | |
| Barkovich scoring system | |||
| Basal ganglia score | 1.0 | ||
| 0, 1 | 32 (88.8) | 25 (89.3) | |
| 2, 3, 4 | 4 (11.1) | 3 (10.7) | |
| Watershed score | 0.3 | ||
| 0, 1, 2 | 32 (88.8) | 22 (78.6) | |
| 3, 4, 5 | 4 (11.1) | 6 (21.4) | |
| Predominant pattern of injury | 0.4 | ||
| Normal | 23 (63.9) | 13 (46.4) | |
| Focal-multifocal | 5 (13.9) | 4 (14.3) | |
| Watershed | 5 (13.9) | 8 (28.6) | |
| BG/T | 3 (8.3) | 2 (7.1) | |
| Total brain injury | 0 | 1 (3.6) | |
| Moderate to severe brain injury* | 5 (13.9) | 6 (21.4) | 0.4 |
*Moderate to severe brain injury defined as WS score of ≥3 or BG/T score ≥2.
BG/T, Basal Ganglia/Thalamus; NICHD, National Institute of Child Health and Human Development; TH, therapeutic hypothermia; WS, Watershed.