Table 4

Area under the curve for distinguishing between concussion and all trauma controls (head and body controls with no concussion)

Hours postinjury traumaGFAPUCH-L1Combination of GFAP and UCH-L1
Enrolment (children) (n=175)0.73 (0.66–0.81)0.59 (0.51–0.67)0.73 (0.65–0.80)
Enrolment (adults) (n=537)0.71 (0.67–0.76)0.64 (0.59–0.69)0.73 (0.68–0.77)
Enrolment (both) (n=712)0.71 (0.67–0.75)0.63 (0.59–0.67)0.72 (0.68–0.76)
4 hours (n=567)0.70 (0.66–0.74)0.61 (0.56–0.65)0.70 (0.66–0.75)
8 hours (n=109)0.75 (0.66–0.84)0.65 (0.54–0.75)0.77 (0.68–0.86)
12 hours (n=80)0.73 (0.62–0.85)0.59 (0.46–0.72)0.73 (0.62–0.85)
16 hours (n=73)0.79 (0.69–0.90)0.64 (0.49–0.80)0.78 (0.68–0.89)
20 hours (n=70)0.73 (0.61–0.86)0.49 (0.33–0.65)0.72 (0.59–0.84)
24 hours (n=67)0.77 (0.64–0.89)0.47 (0.31–0.63)0.75 (0.63–0.88)
36 hours (n=46)0.77 (0.63–0.91)0.59 (0.41–0.77)0.78 (0.64–0.92)
48 hours (n=40)0.81 (0.68–0.95)0.55 (0.37–0.74)0.80 (0.66–0.93)
60 hours (n=33)0.85 (0.71–0.98)0.58 (0.39–0.77)0.86 (0.73–0.98)
72 hours (n=32)0.80 (0.64–0.95)0.51 (0.29–0.73)0.76 (0.59–0.94)
84 hours (n=20)0.85 (0.67–1.00)0.44 (0.18–0.69)0.77 (0.56–0.98)
96 hours (n=17)0.75 (0.51–0.98)0.33 (0.07–0.60)0.67 (0.41–0.92)
108 hours (n=8)0.67 (0.26–1.00)0.17 (0–0.47)0.33 (0–0.71)
120 hours (n=8)0.80 (0.48–1.00)0.30 (0–0.69)0.77 (0.42–1.00)
132 hours (n=4)0.75 (0.20–1.00)0 (0–0)0.50 (0–1.00)
144 hours (n=6)0.75 (0.34–1.00)0 (0–0)0.50 (0.01–0.99)
156 hours (n=6)0.75 (0.34–1.00)0.38 (0–0.85)0.63 (0.15–1.00)
168 hours (n=4)0.75 (0.20–1.00)0.13 (0–1.00)0.63 (0–1.00)
  • In this table, performance of GFAP and UCH-L1 alone and in combination is shown.

  • GFAP, glial fibrillary acidic protein; UCH-L1, ubiquitin C-terminal hydrolase.