Table 3

Area under the curve for distinguishing between concussion and head trauma controls (no concussion symptoms) in patients with head trauma

Hours postinjuryGFAPUCH-L1Combination of GFAP and UCH-L1
Enrolment (children) (n=128)0.64 (0.54–0.73)0.54 (0.43–0.66)0.63 (0.53–0.72)
Enrolment (adults) (n=392)0.66 (0.61–0.71)0.58 (0.51–0.64)0.66 (0.61–0.72)
Enrolment (both) (n=520)0.65 (0.60–0.70)0.56 (0.51–0.62)0.65 (0.60–0.70)
4 hours (n=421)0.62 (0.57–0.68)0.55 (0.49–0.61)0.62 (0.57–0.88)
8 hours (n=99)0.72 (0.61–0.82)0.61 (0.49–0.73)0.72 (0.61–0.82)
12 hours (n=74)0.69 (0.55–0.82)0.51 (0.37–0.66)0.67 (0.54–0.80)
16 hours (n=69)0.76 (0.64–0.88)0.58 (0.39–0.76)0.74 (0.62–0.85)
20 hours (n=65)0.68 (0.53–0.83)0.41 (0.23–0.59)0.66 (0.52–0.81)
24 hours (n=64)0.74 (0.60–0.88)0.40 (0.24–0.56)0.72 (0.59–0.86)
36 hours (n=44)0.76 (0.61–0.91)0.56 (0.37–0.75)0.76 (0.61–0.92)
48 hours (n=38)0.81 (0.67–0.95)0.52 (0.32–0.73)0.79 (0.64–0.93)
60 hours (n=31)0.86 (0.73–1.00)0.54 (0.34–0.74)0.86 (0.73–1.00)
72 hours (n=30)0.78 (0.60–0.95)0.43 (0.20–0.66)0.71 (0.51–0.91)
84 hours (n=19)0.84 (0.65–1.00)0.37 (0.13–0.62)0.74 (0.52–0.97)
96 hours (n=16)0.75 (0.51–0.99)0.28 (0.02–0.55)0.65 (0.38–0.91)
108 hours (n=8)0.67 (0.26–1.00)0.17 (0–0.47)0.33 (0–0.71)
120 hours (n=7)0.80 (0.46–1.00)0.20 (0–0.58)0.70 (0.30–1.00)
132 hours (n=4)0.75 (0.20–1.00)0 (0–0)0.50 (0–1.00)
144 hours (n=6)0.75 (0.20–1.00)0 (0–0)0.50 (0.01–0.99)
156 hours (n=6)0.75 (0.34–1.00)0 (0–0)0.50 (0.01–0.99)
168 hours (n=4)0.75 (0.20–1.00)0.13 (0–1.00)0.63 (0–1.00)
  • In this table, performance of GFAP and UCH-L1 alone and in combination is shown.

  • GFAP, glial fibrillary acidic protein; UCH-L1, ubiquitin C-terminal hydrolase.