Table 5

Estimated sensitivities and specificities of different body parts/systems from studies included in systematic review, with 95% CI in square brackets

Author, yearBody partTotal sample sizeSample size with autopsyExcludedTPFNFPTNSensitivity, % (95% CI)*Specificity, % (95% CI)*
ND autopsyND
PMUS
No autopsy
Neurological
Votino et al, 201820 Brain8866174510174887.5 (59.8 to 97.1)86.6 (75.3 to 93.2)
Prodhomme et al, 201510 Brain16916900NA841007588.9 (81.1 to 93.8)99.3 (94.0 to 99.9)
Tuchtan et al, 201819 Brain757500NA22514780.4 (62.4 to 91.0)96.9 (87.8 to 99.3)
Prodhomme et al, 201510 Spine16916900NA180015197.4 (79.1 to 99.7)99.6 (96.9 to 100.0)
Tuchtan et al, 201819 Spine757500NA10006595.5 (67.9 to 99.5)99.2 (93.1 to 99.9)
Kang et al, 201917 Brain
and spine
123705313NA138113861.4 (40.8 to 78.5)77.0 (63.7 to 86.5)
Cardiothoracic
Prodhomme et al, 201510 Thoracic16916900NA101015887.5 (59.8 to 97.1)99.7 (97.1 to 100.0)
Kang et al, 201917 Thoracic123123021NA514208427.5 (12.8 to 49.4)80.4 (71.9 to 87.0)
Tuchtan et al, 201819 Thoracic757500NA6206772.2 (40.2 to 91.0)99.3 (93.3 to 99.9)
Prodhomme et al, 201510 Cardiac16916900NA29015820.8 (6.7 to 49.1)99.7 (97.1 to 100.0)
Kang et al, 201917 Cardiac123122124NA1313187850.0 (32.4 to 67.6)81.0 (72.0 to 87.5)
Tuchtan et al, 201819 Cardiac757500NA41805319.6 (8.3 to 39.5)99.1 (91.7 to 99.9)
Votino et al, 201820 Cardiac and thoracic888802NA16256586.8 (65.5 to 95.8)92.3 (83.7 to 96.5)
Abdominal
Votino et al, 201820 Whole abdomen888802NA12247083.3 (58.4 to 94.7)94.0 (86.2 to 97.5)
Kang et al, 201917 Whole abdomen123123019NA1711237260.3 (42.4 to 75.9)75.5 (66.0 to 83.0)
Prodhomme et al, 201510 Gastrointestinal16916900NA1510014459.6(40.7 to 76.0)99.7 (96.8 to 100.0)
Tuchtan et al, 201819 Gastrointestinal757500NA2017283.3 (31.0 to 98.2)98.0 (91.7 to 99.5)
Prodhomme et al, 201510 Urinary system16916900NA372013093.7 (81.8 to 98.0)99.6 (96.4 to 100.0)
Tuchtan et al, 201819 Urinary system757500NA9106586.4 (57.1 to 96.8)99.2 (93.1 to 99.9)
  • *Sensitivities, specificities and associated 95% CI are calculated using the standard univariate approach while making an adjustment of 0.5 for zero frequencies where necessary.

  • FN, false negative; FP, false positive; NA, not applicable; ND, non-diagnostic; PMUS, post-mortem ultrasound; TN, true negative; TP, true positive.