Table 1

Background characteristics

Included (n=43)Eligible, not included (n=48)
Treatment (n=21)Control (n=22)
Sex, n (%)
 Male4 (19)6 (27)14 (29)
 Female17 (81)16 (73)34 (71)
Age (years), mean (SD)17.7 (1.4)16.9 (1.7)17.4 (1.4)
BMI (kg/m2), mean (SD)22.5 (3.3)21.6 (2.3)22.1 (2.7)
Adheres to Canada 2003 criteria, n (%)
 Yes3 (14)7 (32)9 (19)
 No18 (86)15 (68)39 (81)
Adheres to Fukuda criteria, n (%)
 Yes5 (24)11 (50)10 (21)
 No16 (76)11 (50)38 (79)
Epstein-Barr virus (EBV) load, copies in blood, n (%)
 Negative (<160)9 (43)13 (65)22 (49)
 Low (1600–2000)7 (33)5 (25)14 (31)
 Moderate/high (>2000)(5 (24)2 (10)9 (20)
EBV-VCA-IgG, titre, median (IQR)152 (107)181 (212)175.5 (198)
Blood cytotoxic T cell (CD8+) count (109 cells/L), mean (SD)0.68 (0.25)0.65 (0.23)0.63 (0.25)
 Efficacy variables
 Chalder Fatigue Questionnaire (CFQ), total sum score, mean (SD)20.0 (3.3)19.4 (2.9)19.1 (4.8)
 Postexertional malaise, score, mean (SD)2.9 (1.5)2.8 (1.3)2.7 (1.2)
 Brief Pain Inventory (BPI), total sum score, mean (SD)10.4 (5.2)13.1 (4.5)11.5 (5.5)
 Karolinska Sleep Questionnaire (KSQ), total sum score, mean (SD)53.0 (14.9)45.6 (10.7)52.0 (13.4)
 Hospital Anxiety and Depression Scale (HADS), total sum score, mean (SD)13.1 (5.8)16.5 (6.5)12.1 (6.2)
 Pediatric Quality of Life Inventory (PedsQL), total average score, mean (SD)67 (14)62 (15)70 (18)
 Functional Disability Inventory, total sum score, mean (SD)12.2 (8.8)13.7 (8.3)10.1 (10.9)
 Steps/day (n), mean (SD)7998 (4598)8376 (3119)9255 (3795)
  • P values are based on χ2 test, Fisher's exact test, Student’s t-test or Mann-Whitney test, as appropriate.

  • BMI, body mass index; VCA, viral capsid antigen.