Midazolam and lidocaine
| Midazolam | n | Study type | Absorption | VD (L/kg) | Metabolite CL (mL/kg/hour) | CL (mL/kg/hour) | t1/2 (hour) |
| Welzing et al40 | 9 | Prospective | / | 5.91 L (median weight not calculated) | / | 154.0 | 7.0 |
| van den Broek et al41 | 53 | Prospective | / | 1.93 | OHM=0.7 HMG 0.02 | 268.0 | 5.0 |
| Favié et al34 | 118 | Prospective | / | 1.55 | OHM=0.969 ↓25.7%=↓8.6%/ºC HMG=0.055 | 100 | / |
| Lidocaine | |||||||
| Favié et al43 | 159 | Mixed | / | 2.66 | MEGX=431 | 506 ↓21.8%=↓7.3%/ºC | / |
| van den Broek et al42 | 48 | Mixed | / | 3.11 | MEGX=166 | 397.0 ↓24.0%=↓8.0%/ºC | 5.5 |