Table 2a

Topiramate and melatonin

TopiramatenStudy typeAbsorptionVD (L/kg)Metabolite CL (mL/kg/hour)CL (mL/kg/hour)t1/2 (hour)
Filippi et al1413ProspectiveAUC=343.2 mg/L/hour//MH=13.87
DH=15.72
MH=29
DH=49
Nuñez-Ramiro et al16106Prospective (RCT)AUC=77.8 mg/L/hour//19.754.1
Marques et al1752Prospective
(RCT)
/0.976/TH=12.6
Postwarm=15.3
↓20.8%=↓6.95%/ºC
/
Melatonin
Balduini et al21 (Melatonine)5ProspectiveAUCss=9.71 µg/mL/hour tabs=2.8 hours1.8/46.026.4