Topiramate and melatonin
| Topiramate | n | Study type | Absorption | VD (L/kg) | Metabolite CL (mL/kg/hour) | CL (mL/kg/hour) | t1/2 (hour) |
| Filippi et al14 | 13 | Prospective | AUC=343.2 mg/L/hour | / | / | MH=13.87 DH=15.72 | MH=29 DH=49 |
| Nuñez-Ramiro et al16 | 106 | Prospective (RCT) | AUC=77.8 mg/L/hour | / | / | 19.7 | 54.1 |
| Marques et al17 | 52 | Prospective (RCT) | / | 0.976 | / | TH=12.6 Postwarm=15.3 ↓20.8%=↓6.95%/ºC | / |
| Melatonin | |||||||
| Balduini et al21 (Melatonine) | 5 | Prospective | AUCss=9.71 µg/mL/hour tabs=2.8 hours | 1.8 | / | 46.0 | 26.4 |